101894-87-5

Upstream product

• 5100-23-2 2-isocyanatobenzoyl chloride 
• 100-66-3 methoxybenzene 
• 108-88-3 toluene 
• 91148-54-8 4-di-(p-anisyl)-1,2-dihydro-3,1-benzoxazin-2(4H)-3-one 
• 2894-51-1 2-amino-4'-chlorobenzophenone 
• 873-77-8 (4-chlorphenyl)magnesium bromide 

Downstream Products

• 926691-84-1 4,4-bis-(4-chloro-phenyl)-6-nitro-1,4-dihydro-benzo[d][1,3]oxazin-2-one 
• 71526-49-3 4,4-bis-(4-chloro-phenyl)-1,4-dihydro-benzo[d][1,3]oxazin-2-one 
• 101879-53-2 3-chloro-9-(4-chloro-phenyl)-acridine 

Relevant academic research and scientific papers

SAR studies of 6-(arylamino)-4,4-disubstituted-1-methyl-1,4-dihydro-benzo[d][1,3]oxazin-2-ones as progesterone receptor antagonists

We previously disclosed that 6-aryl benzoxazin-2-ones were PR modulators. In a continuation of this work we examined the SAR of new 6-arylamino benzoxazinones and found the targets 1-25, with an extra amino linker between the pendent 6-aryl groups and ben

Friedel-Crafts Acylation of Some Aromatic Compounds with 2-Isocyanatobenzoyl Chloride

Friedel-Crafts acylation of benzene, toluene, anisole and chlorobenzene with 2-isocyanatobenzoyl chloride (1) afford either 2-aminobenzophenones (2) or 4,4-diaryl-1,2-dihydro-3,1-benzoxazin-2(4H)-ones (3) as major products depending on reaction temperature and/or substrate reactivity.Other minor products isolated are 3-aryl-1,2,3,4-tetrahydroquinazoline-2,4-diones (4), 6,12-diaryldibenzodiazocines (6) and 2-aminophenyl-α,α-diarylmethanols (7).The formation of 2 and 3 has been shown to take place via a common intermediate complex to which the cyclic 4-aryl-3,1-benzoxazinonium ion structure (12) has been assigned on the basis of its rection with methanol and 2-aminobenzophenone.While the formation of 6 occurs through the intermediate complex (12), 4-aryliminoquinazolin-2-ones (5) are formed most probably from the 1-AlCl3 complex.