102-03-4

Basic information

• Product Name: N-ACETYL-N'-PHENYLUREA
• Synonyms: 1-acetyl-3-phenyl-ure;n-((phenylamino)carbonyl)-acetamid;phenylureidoaceticacid;N-PHENYL-N'-ACETYLUREA;N-ACETYL-N'-PHENYLUREA;SYM-ACETYLPHENYL UREA;1-acetyl-3-phenylurea;N-[(Phenylamino)carbonyl]acetamide
• CAS NO: 102-03-4
• Molecular Formula: C₉H₁₀N₂O₂
• Molecular Weight: 178.19
• EINECS: 202-999-0
• Mol File: 102-03-4.mol

Chemical Properties

• Melting Point: 183 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.229g/cm³
• Refractive Index: 1.587
• PKA: 12.45±0.70(Predicted)
• CAS DataBase Reference: N-ACETYL-N'-PHENYLUREA(CAS DataBase Reference)
• NIST Chemistry Reference: N-ACETYL-N'-PHENYLUREA(102-03-4)
• EPA Substance Registry System: N-ACETYL-N'-PHENYLUREA(102-03-4)

Safety Data

• Hazardous Substances Data: 102-03-4(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
N-Acetyl-N'-phenylurea is used as an intermediate in the preparation of various urea compounds through the condensation of carbamates with amines. This process allows for the synthesis of a wide range of urea-based compounds with diverse applications in different industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-Acetyl-N'-phenylurea can be used as a building block for the development of new drugs with potential therapeutic applications. Its unique structure and reactivity make it a valuable component in the design and synthesis of novel pharmaceutical agents.
Used in Agrochemical Industry:
N-Acetyl-N'-phenylurea can also be utilized in the agrochemical industry for the development of new pesticides and herbicides. Its ability to form urea derivatives with various functional groups makes it a promising candidate for the creation of effective and targeted agrochemical products.

InChI:InChI=1/C9H10N2O2/c1-7(12)10-9(13)11-8-5-3-2-4-6-8/h2-6H,1H3,(H2,10,11,12,13)

Upstream product

• 64-10-8 phenyl carbamate 
• 108-24-7 acetic anhydride 
• 55-21-0 benzamide 
• 89088-94-8 N-Bromacetamid-Natrium 
• 62-53-3 aniline 
• 2911-21-9 2,4-dioxo-6-methyl-3,4-dihydro-2H-1,3-oxazine 
• 56-23-5 tetrachloromethane 
• 2597-54-8 ethyl acetylcarbamate 
• 1132-44-1 1-acetyl-3-phenylthiourea 
• 60-35-5 acetamide 
• 64-19-7 acetic acid 
• 372-09-8 cyanoacetic acid 
• 15837-45-3 6-amino-1-phenyluracil 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 603-54-3 N,N-diphenylurea 
• 67080-96-0 N-acetyl-N'-(4-sulfamoyl-phenyl)-urea 
• 5657-41-0 N³-(4-sulfamoylphenyl)urea 
• 32767-01-4 N-acetyl-N'-(4-bromo-phenyl)-urea 
• 67080-67-5 N-acetylcarbamoyl-sulfanilyl chloride 

Relevant articles and documents

Heterocyclic rearrangements in constrained media. A zeolite-directed photorearrangement of 1,2,4-oxadiazoles

(Chemical Equation Presented) The first intrazeolite-photoinduced rearrangement of a five-membered heterocycle is reported. A completely different behavior compared to solution irradiations has been observed. The zeolite's role in directing the photoreaction of 3-phenyl-1,2,4-oxadiazoles toward the formation of the corresponding 1,3,4-oxadiazoles in a ring contraction-ring expansion route is discussed.

Synthesis of N-benzothiazol-2-yl-amides by an iron-catalyzed oxidative C(sp2)-H functionalization

Catalytic synthesis of N-benzothiazol-2-yl-amides from 1-acyl-3-(phenyl) thioureas was achieved in the presence of an iron catalyst through C(sp 2)-H functionalization and C-S bond formation. Various N-benzothiazol-2-yl-amides were selectively obtained in good yields. Georg Thieme Verlag Stuttgart, New York.

In situ slow release of isocyanates: Synthesis and organocatalytic application of N-acylureas

A novel, efficient, and operationally simple one-pot synthesis of both, symmetrical and unsymmetrical N-acylureas from carboxamides and in situ generated isocyanates (from N,N-dibromo-p-toluenesulfonamide) in the presence of a mild base at rt is reported. The protocol avoids the tedious isolation and purification steps of hazardous isocyanates. The first application of these acylureas to the catalysis through hydrogen bonding is also demonstrated.

PYRIDO [2, 3-D] PYRIMIDINES AS WNT ANTAGONISTS FOR TREATMENT OF CANCER AND ARTHRITIS

Compounds according to the general formula (I) their solvates, hydrates, esters and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer

Heterocyclic Transformations. Part 5: Studies in Reactions of 6-Methyl-1,3-oxazine-2,4(3H)-dione with Arylamines - a Facile Synthesis of 1-Aryl-6-methyluracils

6-Methyl-1,3-oxazine-2,4(3H)-dione 1 reacts with 2 equiv. arylamines 3 at 150-160 deg C to give 1-aryl-6-methyluracils 5 or 1-aryl-3-(3-aryliminobutanoyl)ureas 4.The latter - as well as mixtures of 1 and 3 (2 equiv.) on refluxing, in isopentanol in some cases or in acetic acid in general - provide a facile synthesis of 5.The role of the stoichiometric excess of arylamines as against an equiv. of an alkylamine in similar reactions has been rationalized.

REACTIONS OF ISOTHIOCYANATES AND ISOCYANATES WITH SOME SILYLATED NITROGEN-CONTAINING NUCLEOPHILES

Aryl isothiocyanates and arylisocyanates react with N,O-bis(trimethylsilyl)acetamide to give N-methyl-N'-arylthioureas and ureas.Also nucleophilic additions of other aprotic nucleophiles (e.g.N-trimethylsilylimidazole, N-trimethylsilylpiperidine and N-trimethylsilylmorpholine) to the N=C=X (X=O,S) group were investigated.