102-46-5Relevant academic research and scientific papers
Improved preparation of 3,3′,4,4′-tetramethyldiphenylethane by self coupling reaciton in aqueous media
Hu, Yu-Lin,Lu, Ming,Liu, Qi-Fa,Ge, Qiang
, p. 1056 - 1063 (2009)
In this article, 3,3′,4,4′-tetramethyldiphenylethane was obtained in 86.5% total yield by self coupling reaction of 3,4-dimethylbenzyl chloride catalyzed by Cu/Cu/2/Cl/2//PEG-600 and promoted by iron in aqueous media and the starting
A highly efficient synthetic method for the preparation of 3,4-dimethylbenzaldehyde from o-xylene in aqueous media
Hu,Lu,Liu,Wei,Liu
, p. 487 - 494 (2010)
In this study, 3,4-dimethylbenzaldehyde was obtained in 82.3% total yield by oxidation of 3,4-dimethylbenzyl chloride with NaNO3/AcOH catalyzed by PEG-600 in aqueous media. The starting material 3,4-dimethylbenzyl chloride was prepared by chloromethylation of o-xylene in CTAB micellar catalytic system. Compared with other synthetic methods, this method not only enhanced the yield, but also afforded an efficient work-up procedure. The structures of the products were confirmed by Elemental analysis,1H NMR and 13C NMR or compared with authentic samples.
Mechanism of solvolysis of substituted benzyl chlorides in aqueous ethanol
Denegri, Bernard,Mati?, Mirela,Va?ko, Monika
supporting information, (2021/11/22)
The mechanism of solvolyses of activated ortho-, meta- and para-substituted benzyl chlorides in aqueous ethanol has been studied by using the Hammett-Brown and Yukawa-Tsuno treatments as well as by correlating logarithms of solvolysis rate constants with relative stabilities of corresponding benzyl carbocations in water calculated at the IEFPCM-M06–2X/6-311+G(3df,3pd) level of theory. Benzyl chlorides containing strong conjugative electron-donors in the para-position solvolyze by the SN1 mechanism, whereas other activated benzyl chlorides solvolyze by the SN2 mechanism via loose transition states.
An experimental and theoretical study on imidazolium-based ionic liquid promoted chloromethylation of aromatic hydrocarbons
Wang, Yun,Xi, Yanli
, p. 2196 - 2199 (2014/03/21)
The chloromethylation of aromatic hydrocarbons proceeded efficiently using the reusable imidazolium-based ionic liquid as promoter. Mild reaction conditions, enhanced rates, improved yields, recyclability of ionic liquids, and reagents' reactivity which is different from that in conventional organic solvents are the remarkable features observed in ionic liquids. The ionic liquids were recycled in three subsequent runs with no decrease in activity. In addition, the results of calculations with the Gaussian 98 suite of program are in good accordance with the experimental outcomes.
BENZODIAZEPINONE COMPOUNDS AND METHODS OF TREATMENT USING SAME
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Page/Page column 65, (2011/04/19)
The invention provides 1,4-benzodiazepinone compounds, pharmaceutical compositions, and methods of treating autoimmune disorders, chronic inflammatory disorders, and hyperproliferative disorders. For example, the 1,4-benzodiazepinone compounds and pharmaceutical compositions are contemplated to be useful for treating rheumatoid arthritis, graft-versus-host disease, inflammatory bowel disease, and the like.
An inexpensive and convenient procedure for chloromethylation of aromatic hydrocarbons by phase transfer catalysis in aqueous media
Hu, Yu Lin,Lu, Ming,Ge, Qiang,Wang, Peng Cheng,Zhang, Sheng Bin,Lu, Ting Ting
experimental part, p. 97 - 102 (2010/08/05)
Reaction of aromatic hydrocarbons catalyzed by a novel catalytic system consisting of zinc chloride, acetic acid, sulfuric acid and PEG-800 in aqueous media under PTC conditions results in chloromethylation in good to excellent yield.
BENZODIAZEPINONE COMPOUNDS USEFUL IN THE TREATMENT OF SKIN CONDITIONS
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Page/Page column 17, (2009/05/28)
The present invention provides a family of benzodiazepinone compounds and pharmaceutical compositions thereof. The present invention also provides methods of treating certain skin conditions, e.g., atopic dermatitis, rosacea, or psoriasis, by administering a benzodiazepinone and methods of reducing the proliferation of keratinocyte cells by exposing such cells to a benzodiazepinone.
Identification of alkylarene chloromethylation products using gas-chromatographic retention indices
Zenkevich,Makarov
, p. 611 - 619 (2008/03/18)
Gas-chromatographic retention indices on standard nonpolar polydimethylsiloxane stationary phases allow identification of products formed by known organic reactions even without using mass-spectrometric data. The efficiency of this approach was demonstrated by the example of identification of previously uncharacterized chloromethyl derivatives of alkylarenes, including structural isomers of compounds containing several chloromethyl groups, directly in reaction mixtures. Chromatographic analysis of such reaction mixtures allows identification of positional isomers of the starting alkylarenes even when they are present simultaneously. The retention indices were determined for the first time for more than 50 alkyl-(chloromethyl)arenes, by-products of chloromethylation, and chloromethyl derivatives of the simplest alkyl phenyl ketones. Nauka/Interperiodica 2007.
[emim]BF4-promoted chloromethylation of aromatic hydrocarbons
Wang, Yun,Shang, Zhi-Cai,Wu, Tian-Xing
, p. 3053 - 3059 (2007/10/03)
The chloromethylation of aromatic hydrocarbons proceeded efficiently using the reusable ionic liquid [emim]BF4 as promoter. The reactions were completed in 5 h at 70°C with good yields and easy workup. Copyright Taylor & Francis Group, LLC.
