102012-64-6

Upstream product

• 631-61-8 ammonium acetate 
• 141-97-9 ethyl acetoacetate 
• 100-52-7 benzaldehyde 
• 132330-15-5 2,6-diphenyl-3-carboethoxy-4-amino-1,2,5,6-tetrahydropyridine 
• 135900-95-7 2,6-diphenyl-3-carboethoxy-4-iminopiperidine 

Downstream Products

• 127316-71-6 2,4-diphenyl-1,2,3,4-tetrahydrobenzopyrido<3,4-c>coumarin 
• 127292-14-2 2,4-diphenyl-8-methyl-1,2,3,4-tetrahydropyrido<3,4-c>coumarin 
• 127292-19-7 3,8-dimethyl-2,4-diphenyl-1,2,3,4-tetrahydropyrido<3,4-c>coumarin 
• 127292-20-0 3-methyl-2,4-diphenyl-1,2,3,4-tetrahydrobenzopyrido<3,4-c>coumarin 
• 127292-17-5 8-methyl-3-acetyl-2,4-diphenyl-1,2,3,4-tetrahydropyrido<3,4-c>coumarin 
• 127292-16-4 3-acetyl-2,4-diphenyl-1,2,3,4-tetrahydrobenzopyrido<3,4-c>coumarin 
• 127292-18-6 3-propionyl-2,4-diphenyl-1,2,3,4-tetrahydrobenzopyrido<3,4-c>coumarin 
• 1103231-24-8 N-chloroacetyl-3-carboxyethyl-2,6-diphenyl-4-hydroxy-Δ3-tetrahydropyridine 
• 1226521-13-6 C₂₂H₂₂BrNO₄ 
• 1226521-16-9 C₂₇H₂₅NO₄ 
• 1187636-65-2 C₂₃H₂₄BrNO₄ 
• 1189584-08-4 C₂₂H₂₃NO₄ 
• 5602-70-0 1-methyl-4-oxo-2,6-diphenyl-piperidine-3-carboxylic acid ethyl ester 
• 104218-02-2 4-oxo-2,6-diphenyl-1-[(4-phenyl-thiazol-2-ylcarbamoyl)-methyl]-piperidine-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

One-Pot Synthesis of Substituted Piperidinones and 3,4-Dihydropyrimidinones Using a Highly Active and Recyclable Supported Ionic Liquid Phase Organocatalyst

1-Ethyl-3-methylimidazolium ethyl sulfate was synthesized and its supported ionic liquid phase form was prepared and used as an organocatalyst for the synthesis of substituted piperidinones and 3,4-dihydropyrimidinones. The ionic liquid was characterized by 1H NMR, 13C NMR, and mass spectrometry. The catalyst is novel, stable, completely heterogeneous, and recyclable for several times and can be easily recovered by filtration. It was characterized with scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and energy-dispersive X-ray spectroscopy techniques. The workup procedures are very simple, and products were obtained in good-to-excellent yields with reasonable purities without the need for further chromatographic purification.

Synthesis, spectral, crystal and antimicrobial studies of biologically potent oxime ethers of nitrogen, oxygen and sulfur heterocycles

Three series of oxime ethers viz, 2,6-diarylpiperidin-4-one O-benzyloximes 5a-o, 2,6-diaryltetrahydropyran-4-one O-benzyloximes 7a-e and 2,6-diaryltetrahydrothiopyran-4-one O-benzyloximes 11a-b and 12a-c were synthesized and stereochemistry is established by their spectral and single crystal analysis. A SAR study has been carried out for the above oxime ethers against a panel of antibacterial (Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi and Escherichia coli) and antifungal agents (Candida albicans, Candida-51, Rhizopus sp., Aspergillus niger, Aspergillus flavus and Cryptococcus neoformans), respectively, using Ciprofloxacin and Amphotericin B as standards. Most of the chloro/methyl/methoxy substituted compounds exerted moderate to good activity against all the tested organisms; moreover, some compounds (5i, 5l, 5n, 5o, 7c2, 7d1, 7d2, 7e, 11b and 12c) exhibited promising activity than standard drugs.

Facile synthesis of 2-amino-5,6,7,8-tetrahydro-5,7-diarylpyrido[4,3-d] pyrimidin-4-ols

2-Amino-5,6,7,8-tetrahydro-5,7-diarylpyrido[4,3-d]pyrimidin-4-ols were synthesized from various ethyl 2,6-diaryl-4-oxopiperidin-3-carboxylates with guanidine hydrochloride in presence of sodium ethoxide. Copyright Taylor & Francis Group, LLC.

A facile synthesis, antibacterial, and antitubercular studies of some piperidin-4-one and tetrahydropyridine derivatives

The raise in clinical significance of multidrug-resistant bacterial pathogens has directed us to synthesize 2,6-diarylpiperidin-4-one and Δ3-tetrahydropyridin-4-ol based benzimidazole and O-arylsulfonyl derivatives. X-ray crystal structure of t