102074-19-1

Basic information

• Product Name: (5-METHYLPYRIDIN-3-YL)METHANOL
• Synonyms: (5-METHYLPYRIDIN-3-YL)METHANOL;3-Pyridinemethanol,5-methyl-(6CI,9CI);3-Hydroxymethyl-5-methylpyridine;5-Methyl-3-pyridineMethano;3-PyridineMethanol,5-Methyl-;5-methy-3-pyridylmethanol;Fumarate R Impurity 1;Rupatadine impurity 3
• CAS NO: 102074-19-1
• Molecular Formula: C₇H₉NO
• Molecular Weight: 123.15
• Product Categories: PYRIDINE
• Mol File: 102074-19-1.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 256℃
• Flash Point: 109℃
• Appearance: /
• Density: 1.092
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.545
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 13.70±0.10(Predicted)
• CAS DataBase Reference: (5-METHYLPYRIDIN-3-YL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (5-METHYLPYRIDIN-3-YL)METHANOL(102074-19-1)
• EPA Substance Registry System: (5-METHYLPYRIDIN-3-YL)METHANOL(102074-19-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 102074-19-1(Hazardous Substances Data)

Usage

General Description

(5-Methylpyridin-3-yl)methanol, also known as 5-methyl-3-pyridylmethanol, is a chemical compound with the molecular formula C7H9NO. It is a derivative of pyridine and belongs to the class of alcohols. (5-METHYLPYRIDIN-3-YL)METHANOL is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and other organic compounds. It is a colorless liquid with a strong odor, and it is soluble in organic solvents like ethanol, acetone, and ether. The compound is also used as a reagent in organic synthesis and as a ligand in coordination chemistry. Additionally, it has potential applications in the development of new materials and as a precursor in the production of fine chemicals.

InChI:InChI=1/C7H9NO/c1-6-2-7(5-9)4-8-3-6/h2-4,9H,5H2,1H3

Upstream product

• 92444-99-0 2-chloro-5-methylpyridine-3-carbaldehyde 
• 3222-49-9 5-methylnicotinic acid 
• 591-22-0 3,5-Lutidine 
• 29681-45-6 5-methylnicotinic acid methyl ester 

Downstream Products

• 158876-82-5 rupatadine 
• 1235342-53-6 3-(bromomethyl)-5-methylpyridine hydrobromide 
• 115017-13-5 (2-Amino-3,5-difluoro-phenyl)-(5-methyl-pyridin-3-yl)-methanone 
• 1007089-84-0 3-(chloromethyl)-5-methylpyridine hydrogen chloride 
• 100910-66-5 5-methyl-3-pyridinecarboxaldehyde 

Relevant articles and documents

Efficient synthesis of 3-(bromomethyl)-5-methylpyridine hydrobromide

5-Methyl-3-(bromomethyl)pyridine is the key intermediate in the synthesis of rupatadine. In this article, a new preparation of 5-methyl-3-(bromomethyl)pyridine hydrobromide is reported, which used 5-methylnicotinic acid as the starting material, with a 65.9% overall yield. This method has the merits of being simple, efficient and environmentally friendly.

New impurity of rupatine fumarate and preparation method and detection method thereof

The invention provides a novel impurity (a compound shown in formula I) of lupatifen fumarate and a preparation method of the novel impurity. The novel impurity can be used for controlling the quality of the lupatifen fumarate and a preparation of the lupatifen fumarate, so that a foundation is set for effectively controlling the quality of lupatifen fumarate bulk drugs and a preparation of the lupatifen fumarate bulk drugs. (the formula structure is shown in the description), wherein an anion X are selected from F, Cl, Br and I; and preferably, the anion X is Br.

Preparation of 5-methyl-3-polybromide methylpyridinio hydrobromide method

The invention relates to a method for preparing 5-methyl-3-bromomethylpyridine hydrobromide. The method comprises a step of preparing methyl 5-methyl nicotinate; a step of preparing 5-methyl-3-pyridinemethanol; a step of preparing 5-methyl-3-pyridinemethanol hydrobromide; and a step of preparing 5-methyl-3-bromomethylpyridine hydrobromide. In the step of preparing methyl 5-methyl nicotinate, esterification of 5-methyl nicotinic acid and thionyl chloride is carried out under heating reflux to obtain methyl 5-methyl nicotinate; in the step of preparing 5-methyl-3-pyridinemethanol, a reduction reaction of methyl 5-methyl nicotinate and sodium borohydride is carried out in an organic solvent to obtain 5-methyl-3-pyridinemethanol; in the step of preparing 5-methyl-3-pyridinemethanol hydrobromide, 5-methyl-3-pyridinemethanol reacts with hydrobromic acid to obtain 5-methyl-3-pyridinemethanol hydrobromide; and in the step of preparing 5-methyl-3-bromomethylpyridine hydrobromide, 5-methyl-3-pyridinemethanol hydrobromide reacts with hydrobromic acid in an organic solvent and water is removed from the reaction system to obtain 5-methyl-3-bromomethylpyridine hydrobromide. According to the method, 5-methyl-3-bromomethylpyridine hydrobromide is obtained by four steps; the process is simple; and yield is high.