102093-87-8Relevant articles and documents
ONE-STEP PROTECTION OF THE NUCLEOSIDE BASE IN THYMIDINE AND URIDINE
Claesen, C. A. A.,Pistorius, A. M. A.,Tesser, G. I.
, p. 3859 - 3862 (1985)
Unprotected thymidine and uridine react with 4-nitrophenylsulfonyl ethene (3) in a base catalyzed Michael type addition to give O4-(4-nitrophenylsulfonylethyl)thymidine (6) and -uridine (7), respectively.The 4-nitrophenylsulfonylethyl group is cleaved within 2.5 hours at 50-55 deg C by concentrated aqueous ammonia, via β-elimination.