21386-32-3

Upstream product

• 13287-76-8 2-(p-nitrophenylthio)ethanol 
• 100-00-5 4-chlorobenzonitrile 
• 1849-36-1 para-nitrobenzenethiol 

Downstream Products

• 102093-85-6 2-(4-nitrophenylsulphonyl)ethyl chloroformate 
• 548740-01-8 2-(4-nitrophenylsulfonyl)ethyl (E)-3-phenyl-2-propenoate 
• 548740-00-7 2-(4-nitrophenylsulfonyl)ethyl 3-phenylpropanoate 
• 102093-86-7 O⁴-(4-nitrophenylsulfonylethyl)thymidine 
• 102093-87-8 O⁴-(4-nitrophenylsulfonylethyl)uridine 
• 916262-77-6 2-[(4-nitrophenyl)sulfonyl]ethyl N-(2-methyl-1-oxopropyl)-L-prolinate 
• 5246-58-2 4-(2'-Hydroxyethylsulphonyl)aniline 
• 35661-55-3 2-p-Nitrophenylsulfonylethylanilid 
• 102002-61-9 phosphoric acid-[2-(4-nitro-benzenesulfonyl)-ethyl ester]-diphenyl ester 

Relevant academic research and scientific papers

DYE AND DYEING METHOD

A dyeing method is provided, which includes dyeing a dye to a fiber by a supercritical fluid, wherein the dye has a chemical structure of:R 1 is C1-6alkyl group, R 2 is C1-6alkyl group, each of R 3 is independently of H or C1-6alkyl group, and R 4 is a single bond or C1-6alkylene group. When R 4 is single bond, R 5 is. When R 4 is C1-6alkylene group, R 5 is H, Br, Cl, or. Each of R 6 is independently of H, Cl, Br, OCH3, or C1-6alkyl group.

Preparing methods of p-aminophenyl-beta-hydroxyethylsulfonyl and p-minophenyl-beta-hydroxyethylsulfonyl sulphonate

The invention relates to preparing methods of p-aminophenyl-beta-hydroxyethylsulfonyl and p-minophenyl-beta-hydroxyethylsulfonyl sulphonate. The preparing methods both comprise the steps that p-aminophenyl-beta-hydroxyethylsulfonyl and hydrogen are used as raw materials, modified framework nickel is used as a hydrogen-adding catalyst, a catalytic hydrogenation reaction is conducted in a solvent toobtain reduction liquid, and modified framework nickel and the solvent in the reduction liquid are separated and removed to obtain p-minophenyl-beta-hydroxyethylsulfonyl sulphonate; according to modified framework nickel, nickel is used as a framework, and modified framework nickel is prepared from, by mass, 75-95 parts of Ni, 3-15 parts of Al and 2-10 parts of metal adjuvant; the metal adjuvantcomprises the combination of any one or at least two of Mo, Cu and Cr. The yield can reach 94% or above; preparation of p-minophenyl-beta-hydroxyethylsulfonyl sulphonate is a continuous production technology, the technology is simplified, the production efficiency is high, the quality is stable, the production cost is low, and the economic benefit and social benefit are obvious.

Dye compounds and resin composition for color filter comprising the same

The present invention relates to a pyridone azo dye compound for a color filter resin composition having excellent solubility and heat resistance, which is represented by the following chemical formula 1 and contains an acrylic group or a meta-acrylic group. The pyridone azo dye compound according to the present invention has excellent solubility and heat resistance with respect to an organic solvent, thereby having higher solubility as a coloring agent of the color filter resin composition than a pigment; and maximizing coloring performance and realizing high color reproducibility by reducing an amount of an additive added for pigment dispersion stability. [Chemical formula 1]COPYRIGHT KIPO 2016

Design, Synthesis, and Evaluation of 2-(arylsulfonyl)oxiranes as Cell-permeable Covalent Inhibitors of Protein Tyrosine Phosphatases

A structure-based design approach has been applied to develop 2-(arylsulfonyl)oxiranes as potential covalent inhibitors of protein tyrosine phosphatases. A detailed kinetic analysis of inactivation by these covalent inhibitors reveals that this class of compounds inhibits a panel of protein tyrosine phosphatases in a time- and dose-dependent manner, consistent with the covalent modification of the enzyme active site. An inactivation experiment in the presence of sodium arsenate, a known competitive inhibitor of protein tyrosine phosphatase, indicated that these inhibitors were active site bound. This finding is consistent with the mass spectrometric analysis of the covalently modified protein tyrosine phosphatase enzyme. Additional experiments indicated that these compounds remained inert toward other classes of arylphosphate-hydrolyzing enzymes, and alkaline and acid phosphatases. Cell-based experiments with human A549 lung cancer cell lines indicated that 2-(phenylsulfonyl)oxirane (1) caused an increase in intracellular pTyr levels in a dose-dependent manner thereby suggesting its cell-permeable nature. Taken together, the newly identified 2-(arylsulfonyl)oxiranyl moiety could serve as a novel chemotype for the development of activity-based probes and therapeutic agents against protein tyrosine phosphatase superfamily of enzymes.

Synthesis and second-order nonlinearities of chiral prolinol-substituted chromophores

A new series of thiophene- and furan-containing chromophores with a chiral prolinol donor and a sulfone acceptor has been synthesized. The UV-vis absorptions, second-order nonlinear optical properties, and X-ray crystal structures are described.

π-deficient 2-(arylsulfonyl)ethyl esters as protecting groups for carboxylic acids

Several π-deficient 2-(arylsulfonyl)ethyl groups have been studied as carboxylic acid protecting groups. The 2-[3,5-bis(trifluoromethyl)phenylsulfonyl]ethyl group is the most easily removed protecting group for acids under mild basic conditions using aqueous NaHCO3.

New base-labile amino-protective groups for peptide synthesis

Modification of the methyl group in 2-(methylsulphonyl)ethanol gave alcohols which could be used to introduce amino-protective groups of the urethane type, which are labile in alkaline media.The cleavage involves β-elimination.Exchange of the methyl group by a phenyl group bearing a function with a negative inductive effect (NO2 or MeSO2) afforded protecting groups with a higher sensitivity to base.The recommended function is a disulphone: 2-ethanol.The function has a somewhat better stability than the Fmoc group, resists catalytic hydrogenolysis, is highly stable in acidic medium and its elimination product does not polymerize spontaneously.The suggested designation of the new protective group is Mpc.

Process for producing aminophenyl-β-hydroxyethylsulfone

A process for producing aminophenyl-β-hydroxyethylsulfone of the formula (I), STR1 which comprises the following steps: (1) condensing nitrohalobenzene with mercaptoethanol in the presence of an alkali hydroxide and at least one reaction medium selected from N-alkyl-substituted amides and sulfoxides to produce mononitrophenyl-β-hydroxyethylsulfide of the formula (II): STR2 (2) oxidizing the mononitrophenyl-β-hydroxyethylsulfide (II) to produce mononitrophenyl-β-hydroxyethylsulfone of the formula (III): STR3 and (3) reducing the mononitrophenyl-β-hydroxyethylsulfone to produce the aminophenyl-β-hydroxyethylsulfone of the formula (I). This compound is useful as an intermediate for aminophenyl-β-sulfatoethylsulfone represented by the following formula: STR4 which is an important intermediate for vinyl sulfone type reactive dyes largely used for dyeing cellulose fiber materials.

ONE-STEP PROTECTION OF THE NUCLEOSIDE BASE IN THYMIDINE AND URIDINE

Unprotected thymidine and uridine react with 4-nitrophenylsulfonyl ethene (3) in a base catalyzed Michael type addition to give O4-(4-nitrophenylsulfonylethyl)thymidine (6) and -uridine (7), respectively.The 4-nitrophenylsulfonylethyl group is cleaved within 2.5 hours at 50-55 deg C by concentrated aqueous ammonia, via β-elimination.