102101-10-0Relevant articles and documents
Highly selective and efficient synthesis of 3-arylamino-substituted 5-aminopyrazole-4-carboxylates under microwave irradiation
Lim, Felicia Phei Lin,Gan, Rowena Xin Yi,Dolzhenko, Anton V.
, p. 775 - 778 (2017)
An improved microwave-assisted method was developed for the preparation of ethyl 5-aminopyrazole carboxylates from ethyl 2-cyano-3-methylthioacrylates and hydrazine. It was shown that using microwave irradiation significantly reduced the reaction time and improved the process selectivity and yield. The reaction proved to be reproducible in different microwave reactors and on large scale, affording the desired products in high yields and purity. A representative library of 3-arylamino-substituted 5-aminopyrazole-4-carboxylates was successfully prepared to assess the scope of the method.
1H and 13C NMR spectral characterization of some antimalarial in vitro 2,4-diamino-10-methylpyrimido[4,5-b]-5-quinolone derivatives
Charris, Jaime E.,Dominguez, Jose N.,Gamboa, Neira,Angel, Jorge,Pina, Nolberto,Guerra, Mayamaru,Michelena, Elba,Lopez, Simon E.
, p. 477 - 479 (2007/10/03)
We report the 1H NMR and 13C NMR chemical shifts and J(H,H), J(H,F) and J(C,F) coupling constants of 13 2,4-diamino-10-methylpyrimido[4,5-b]-5-quinolone derivatives, some of them with moderate activity against Plasmodium falciparum i