1021188-73-7

Basic information

• Product Name: tert-butyl (2-benzamidoethyl)carbamate
• Synonyms: tert-butyl (2-benzamidoethyl)carbamate
• CAS NO: 1021188-73-7
• Molecular Weight: 264.324
• Mol File: 1021188-73-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: tert-butyl (2-benzamidoethyl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (2-benzamidoethyl)carbamate(1021188-73-7)
• EPA Substance Registry System: tert-butyl (2-benzamidoethyl)carbamate(1021188-73-7)

Safety Data

• Hazardous Substances Data: 1021188-73-7(Hazardous Substances Data)

Upstream product

• 57260-73-8 N-BOC-1,2-diaminoethane 
• 134-81-6 benzil 
• 93-58-3 benzoic acid methyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 98-88-4 benzoyl chloride 

Downstream Products

• 1009-17-2 N-(2-amino-ethyl)-benzamide 
• 1502-45-0 N-(2-aminoethyl)benzamide hydrochloride 

Relevant articles and documents

UV-Light-Induced N-Acylation of Amines with α-Diketones

Herein, we develop a mild method for N-acylation of primary and secondary amines with α-diketones induced by ultraviolet (UV) light. Forty-six examples with various functional groups are explored at room temperature with irradiation by three 26 W UV lamps (350-380 nm). The yield reaches 97%. The gram scale experiment product yield is 76%. Moreover, this system can be applied to the synthesis of several amino acid derivatives. Mechanistic studies show that benzoin is generated in situ from benzil under UV irradiation.

An Unconventional Reaction of 2,2-Diazido Acylacetates with Amines

We have discovered that 2,2-diazido acylacetates, a class of compounds with essentially unknown reactivity, can be coupled to amines through a new strategy that does not involve any reagents. 2,2-Diazido acetate is the unconventional leaving group under carbon–carbon bond cleavage. This reaction leads to the construction of amide bonds, tolerates various functionalities and is performed equally well in numerous solvents under experimentally simple conditions. We also demonstrate that the isolation of the 2,2-diazido acylacetate compounds can be circumvented: Acylacetates were easily fragmented when treated with (Bu4N)N3 and iodine in the presence of an amine at room temperature. By using this method, a broad range of acylacetates with various structural motifs were directly transformed into amides.

Discovery and optimization of adamantane carboxylic acid derivatives as potent diacylglycerol acyltransferase 1 inhibitors for the potential treatment of obesity and diabetes

Abstract We have developed a series of adamantane carboxylic acid derivatives exhibiting potent diacylglycerol acyltransferase 1 (DGAT1) inhibitory activities. Optimization of the series led to the discovery of E-adamantane carboxylic acid compound 43c, which showed excellent in vitro activity with an IC50 value of 5 nM against human and mouse DGAT1, also good druggability as well as microsomal stability and safety profiles such as hERG, CYP and cytotoxicity. Compound 43c significantly reduced plasma triglyceride levels in vivo (in rodents and zebrafish) and also showed bodyweight gain reduction and glucose area under curve (AUC) lowering efficacy in diet-induced obesity (DIO) mice.