1502-45-0

Basic information

• Product Name: N-(2-AMinoethyl)benzaMide HCl
• Synonyms: N-(2-AMinoethyl)benzaMide HCl;N-(2-aminoethyl)benzamide hydrochloride;Benzamide, N-(2-aminoethyl)-, monohydrochloride
• CAS NO: 1502-45-0
• Molecular Formula: C₉H₁₂N₂O*ClH
• Molecular Weight: 200.66532
• Mol File: 1502-45-0.mol

Chemical Properties

• Boiling Point: 376.8°Cat760mmHg
• Flash Point: 181.7°C
• Appearance: /
• Density: 1.094g/cm³
• Vapor Pressure: 7.05E-06mmHg at 25°C
• Refractive Index: 1.553
• CAS DataBase Reference: N-(2-AMinoethyl)benzaMide HCl(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-AMinoethyl)benzaMide HCl(1502-45-0)
• EPA Substance Registry System: N-(2-AMinoethyl)benzaMide HCl(1502-45-0)

Safety Data

• Hazardous Substances Data: 1502-45-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
N-(2-AEBA) HCl is used as a research compound for studying the effects of benzamide analogs on biological processes, which aids in understanding their potential therapeutic applications.
Used in Drug Development:
N-(2-AEBA) HCl is used as a potential therapeutic agent in the development of new treatments for conditions such as cancer, neurological disorders, and metabolic diseases, due to its potential biological activity.
Used in Chemical Synthesis:
N-(2-AEBA) HCl is used as a precursor in the production of other chemical compounds, contributing to the synthesis of various substances with specific applications.
Used in Laboratory Research:
N-(2-AEBA) HCl is utilized in laboratories for conducting experiments and research to explore its properties and potential uses in different fields of science and medicine.

InChI:InChI=1/C9H12N2O/c10-6-7-11-9(12)8-4-2-1-3-5-8/h1-5H,6-7,10H2,(H,11,12)

Upstream product

• 1021188-73-7 tert-butyl (2-benzamidoethyl)carbamate 
• 98-88-4 benzoyl chloride 
• 107-15-3 ethylenediamine 

Downstream Products

• 58027-10-4 N-{2-[3-(4-Acetylamino-phenoxy)-2-hydroxy-propylamino]-ethyl}-benzamide 
• 83019-52-7 N-[2-(2-Hydroxy-3-phenoxy-propylamino)-ethyl]-benzamide 
• 53671-96-8 N-{2-[2-Hydroxy-3-(4-hydroxy-phenoxy)-propylamino]-ethyl}-benzamide 

Relevant articles and documents

New analogues of N-(2-aminoethyl)-4-chlorobenzamide (Ro 16-6491). Some of the most potent monoamine oxidase-B inactivators

A series of halo- and nitro-substituted analogues of N-(2- aminoethyl)benzamide has been synthesized. All of the compounds are competitive, time-dependent inhibitors of monoamine oxidase-B (MAO-B), but upon dialysis complete return of enzyme activity is observed for all compounds. Therefore, these are mechanism-based reversible inhibitors of MAO- B. The relative potencies of the compounds are rationalized in terms of steric and hydrophobic effects.

Discovery and optimization of adamantane carboxylic acid derivatives as potent diacylglycerol acyltransferase 1 inhibitors for the potential treatment of obesity and diabetes

Abstract We have developed a series of adamantane carboxylic acid derivatives exhibiting potent diacylglycerol acyltransferase 1 (DGAT1) inhibitory activities. Optimization of the series led to the discovery of E-adamantane carboxylic acid compound 43c, which showed excellent in vitro activity with an IC50 value of 5 nM against human and mouse DGAT1, also good druggability as well as microsomal stability and safety profiles such as hERG, CYP and cytotoxicity. Compound 43c significantly reduced plasma triglyceride levels in vivo (in rodents and zebrafish) and also showed bodyweight gain reduction and glucose area under curve (AUC) lowering efficacy in diet-induced obesity (DIO) mice.

BENZOIMIDAZOLE DERIVATIVES AND GLYCOGEN SYNTHASE KINASE-3 BETA INHIBITORS CONTAINING THE SAME

Benzoimidazole Derivatives are provided. The compounds of the present invention are useful for Glycogen Synthase Kinase-3 Beta Inhibitors.

MTP INHIBITING TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID DERIVATIVES

The present invention is concerned with novel tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds

BENZAMIDE DERIVATIVES

Benzamides of the formula I wherein R1 and R2 each independently is hydrogen, halogen, lower alkyl, lower alkoxy, cyano, trifluoromethyl, sulfamoyl, mono(lower alkyl)sulfamoyl or di(lower alkyl)sulfamoyl or R1 and R2 on adjacent carbon atoms together are