1021875-33-1Relevant academic research and scientific papers
Thermal reaction of a columnar assembled diacetylene macrocycle
Xu, Yuewen,Smith, Mark D.,Geer, Michael F.,Pellechia, Perry J.,Brown, Julius C.,Wibowo, Arief C.,Shimizu, Linda S.
, p. 5334 - 5335 (2010)
Reported is a macrocyclic diacetylene that assembled into columns to afford porous crystals. Heating this assembly initiated a topochemical polymerization of the preorganized diacetylene units to give covalent conjugated polydiacetylenes. These stable con
A small molecule peptidomimetic that binds to c-KIT1 G-quadruplex and exhibits antiproliferative properties in cancer cells
Chauhan, Ajay,Paladhi, Sushovan,Debnath, Manish,Mandal, Samir,Das, Rabindra Nath,Bhowmik, Sudipta,Dash, Jyotirmayee
, p. 4422 - 4429 (2014)
A modular synthesis of l-proline derived peptidomimetics has been developed using the CuI catalyzed Huisgen cycloaddition between an azido prolinamide with pyridine and benzene dicarboxamide containing dialkynes. F?rster Resonance Energy Transfer (FRET) melting assay provided an initial indication that the pyridyl analogue can stabilize the c-KIT1 quadruplex DNA. A competitive FRET-melting assay and Fluorescent Intercalator Displacement (FID) assay suggest that the pyridyl ligand shows excellent selectivity for c-KIT1 quadruplex over duplex DNA and other investigated G-quadruplexes. Molecular docking studies indicate that the pyridyl ligand can adopt unique conformations upon binding to c-KIT1 quadruplex due to the presence of intramolecular hydrogen bonds. The pyridyl ligand can perturb cell cycle progression and induce necrotic cell death of human hepatocellular liver carcinoma HepG2 cells.
A Novel Fluorescent Chemosensor for cu (II) Ion: Click Synthesis of Dual-Bodipy Including the Triazole Groups and Bioimaging of Yeast Cells
Kursunlu, Ahmed Nuri,Ozmen, Mustafa,Güler, Ersin
, p. 1321 - 1329 (2019)
A fluorescent chemosensor including dual Bodipy units (d-BODIPY) was improved for selective copper (II) sensing in half-aqueous samples. The sensor d-BODIPY has a highly selective and sensitive detection towards Cu (II) over the studied competing for meta
Polyvalent Azasugar derivatives and its synthetic method
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Paragraph 0131; 0138; 0139, (2017/01/31)
The invention provides derivatives of multivalent azasugar of 3,4,5-trihydroxyl-1-octylpiperidine-2-ketone having a general formula (I), and a synthetic method of the derivatives. According to the derivatives and the preparation method thereof provided by the invention, multivalent azasugar is formed by connecting (3S,4R,5S)-3,4,5-trihydroxyl-1-(8-aminooctyl)piperidine-2-ketone as a monomer with a polyatomic acid or polyacyl chloride, or connecting (3S,4R,5S)-3,4,5-trihydroxyl-1-(8-azidooctyl)piperidine-2-ketone as a monomer with a derivative of a polyatomic acid, polyhydric alcohol or polyacyl chloride The multivalent azasugar synthesized by the method provided by the invention has the potential of serving as a pharmacological molecular chaperone in CMT (Pharmacological Chaperone Molecular therapy) for treating Gaucher disease, and thereby having a high application value.
Halide binding and self-assembling behavior of Triazole-based acyclic and cyclic molecules
Haridas,Sahu, Srikanta,Venugopalan
experimental part, p. 727 - 733 (2011/03/19)
The present study demonstrates the use of triazole moiety in designing molecules endowed with the ability for self-assembly and molecular recognition. The receptors 7a and 9a having open structures bind to fluoride ion with good affinity. Various cyclopha
Synthesis of novel multidentate carbohydrate-triazole ligands
Ziegler, Thomas,Hermann, Catrin
, p. 2166 - 2169 (2008/09/20)
Cu(I)-catalyzed 1,3-dipolar cycloaddition (click reaction) of 1 mol equiv of N,N′-di-prop-2-ynyl-phthalamide (1a), N,N′-di-prop-2-ynyl-isophthalamide (1b), and pyridine-2,6-dicarboxylic acid bis-prop-2-ynylamide (1c), respectively with 2 mol equiv of 2,3,
