102202-87-9

Basic information

• Product Name: Bis(phthaliMidylpropyl)aMine
• Synonyms: Bis(phthaliMidylpropyl)aMine
• CAS NO: 102202-87-9
• Molecular Formula: C₂₂H₂₁N₃O₄
• Molecular Weight: 391.41984
• EINECS: -0
• Mol File: 102202-87-9.mol
• Article Data: 21

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Bis(phthaliMidylpropyl)aMine(CAS DataBase Reference)
• NIST Chemistry Reference: Bis(phthaliMidylpropyl)aMine(102202-87-9)
• EPA Substance Registry System: Bis(phthaliMidylpropyl)aMine(102202-87-9)

Safety Data

• Hazardous Substances Data: 102202-87-9(Hazardous Substances Data)

Upstream product

• 56-18-8 bis(3-aminopropyl)amine 
• 22509-74-6 N-ethoxycarbonylphthalimide 
• 85-44-9 phthalic anhydride 

Downstream Products

• 107886-36-2 N,N-bis(3-phthalimidopropyl)benzylamine 
• 164913-26-2 N¹,N⁹-dibenzyl-N⁵,N¹³-ditosyl-1,5,9,13-tetraazacyclohexadecane 
• 1555-71-1 N1-(3-amino-propyl)-N1-benzyl-propane-1,3-diamine 
• 47771-56-2 N⁴-benzyl-N¹,N⁷-ditosyl-4-aza-1,7-heptanediamine 
• 313983-96-9 [4-({bis-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid 
• 313983-90-3 [4-({bis-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-carbamoyloxy}-methyl)-phenoxy]-acetic acid allyl ester 
• 66322-78-9 N,N,N-tris(3-phthalimidopropyl)amine 

Relevant articles and documents

Oligonucleotides Containing Aminated 2′-Amino-LNA Nucleotides: Synthesis and Strong Binding to Complementary DNA and RNA

Mono- and diaminated 2′-amino-LNA monomers were synthesized and introduced into oligonucleotides. Each modification imparts significant stabilization of nucleic acid duplexes and triplexes, excellent sequence selectivity, and significant nuclease resistance. Molecular modeling suggested that structural stabilization occurs via intrastrand electrostatic attraction between the protonated amino groups of the aminated 2′-amino-LNA monomers and the host oligonucleotide backbone.

Polyamines. III. Spectroscopic properties of N,N-bis-(phthalimidopropyl)-N-octylamine and supramolecular interactions in its crystals

A new derivative of polyamine, N,N-bis-(phthalimidopropyl)-N-octylamine has been synthesized and its structure studied by X-ray diffraction, FTIR, 1H and 13C NMR spectroscopy. The B3LYP and DFT calculations have been carried out. The molecular conformation of N,N-bis-(phthalimidopropyl)-N-octylamine is folded and stabilized by an intramolecular C{single bond}H?O hydrogen bond. A close similarity to the conformation of N,N-bis-(phthalimidopropyl)-N-propylamine has been found. The both molecules differ by the length of the saturated chains on the N-amine atom. The long N-octyl chain substituent gives rise to the supramolecular structure which is different to that one formed by the N-propyl derivative. The supramolecular structure is driven by weak C{single bond}H?O and π?π interactions. The optimized bond lengths as well as bond angles for N,N-bis-(phthalimidopropyl)-N-octylamine calculated by B3LYP/6-31G(d,p) approach are compared with the X-ray data. The screening constants for 13C and 1H atoms have been calculated by the GIAO/B3LYP/6-31G(d,p) approach and analyzed. Linear correlations between the experimental 1H and 13C chemical shifts and the computed screening constants have been obtained.

Synthesis of a symmetrically branched template for parallel α-helix dimers

The synthesis of a symmetrical diamino acid is described for the assembly of parallel α-helices in solid phase peptide synthesis. This handle is designed to replace the C-terminal half of a class of DNA binding proteins, the Leucine Zipper.

Unusual specificity of a receptor for Nd3+ among other lanthanide ions for selective colorimetric recognition

A rare example of a reversible recognition of Nd3+ by a newly synthesized molecular receptor (L1), having a diazo group as the reporter functionality, is reported. Studies revealed that this receptor eventually forms a [Nd3+]2L1 type complex, through the formation of the intermediate complex [Nd3+]L 1 following a two-step equilibrium process. Respective equilibrium constants for two successive processes were evaluated based on data obtained from the systematic fluorescence titration. Formation of [Nd3+] 2L1 caused a detectable change in color, and associated affinity constants were also evaluated from spectrophotometric titration data. A rather unusual binding mode of L1 for Nd3+ ion is established by various spectroscopic studies. The remarkable specificity of L1 for Nd3+, constitutes a rare example of a highly selective receptor for this ion in the presence of excess of all other lanthanide ions.

Polyamines. I. Spectroscopic properties of N,N-bis-(phthalimidopropyl)-N-propylamine and supramolecular interactions in its crystals

A new derivative of polyamine, N,N-bis-(phthalimidopropyl)-N-propylamine (1) has been synthesized and its structure studied by X-ray diffraction, FTIR, Raman, 1H and 13C NMR spectroscopies. The B3LYP and DFT calculations have been carried out. The molecular structure of N,N-bis-(phthalimidopropyl)-N-propylamine (1) presents the first case of a folded conformation for this group of compounds which is stabilized by an intramolecular hydrogen bond C-H?O. Neither C-H?π, π?π or C{double bond, short}O?C{double bond, short}O interactions operate in this case. Also the supramolecular structure is stabilized by weak C-H?O and C-H?π hydrogen bonds. The optimized bond lengths as well as bond angles for 1 calculated by B3LYP/6-31G(d,p) approach are compared with the X-ray data. The screening constants for 13C and 1H atoms have been calculated by the GIAO/B3LYP/6-31G(d,p) approach and analyzed. Linear correlations between the experimental 1H and 13C chemical shifts and the computed screening constants have been obtained.

COMPOUNDS, COMPOSITONS AND METHODS RELATED TO ANTIMICROBIAL APPLICATIONS

The present disclosure is in the field of polymers and pharmaceuticals/antimicrobials. The disclosure provides compounds based on SNAP (synthetic novel antimicrobial polymer) technology, compositions and methods of managing microbial infections including surgical site infections (SSIs). The present compounds are used as a management/therapeutic strategy to target microbial infections and have advantages including excellent antimicrobial potency, biofilm disruption ability, broad spectrum activity against various organisms covering both gram negative and gram positive bacteria as well as fungal pathogens, and low toxicity profile to ensure a healthy therapeutic window for use in humans.

MOLECULAR DESIGN TOWARD DUAL-MODALITY PROBES FOR RADIOISOTOPE-BASED IMAGING (PET OR SPECT) AND MRI

In some aspects, the present invention provides novel ligands, which may be used to make novel dual-modality imaging agents, for example, for PET and MRI imaging. In further aspects, by the present disclosure also provides methods of use and methods of preparation of the novel ligands, metal complexes, and imaging agents thereof.