107886-36-2

Upstream product

• 5460-29-7 2-(3-bromopropyl)isoindole-1,3-dione 
• 100-46-9 benzylamine 
• 102202-87-9 N,N-bis(phthalimidopropyl)amine 
• 100-39-0 benzyl bromide 
• 85-44-9 phthalic anhydride 
• 56-18-8 bis(3-aminopropyl)amine 

Downstream Products

• 107886-45-3 C₅₁H₅₇N₅O₄ 
• 107886-38-4 N⁴,N⁸,N¹²-tribenzyl-N¹,N¹⁵-bis(phthaloyl)-,8,12-triazapentadecane 
• 107886-39-5 1,15-diamino-N⁴,N⁸,N¹²-tribenzyl-4,8,12-triazapentadecane 
• 107886-37-3 N¹,N⁴,N⁷-tribenzyl-7-aza-1,7-diaminoheptane 
• 80525-58-2 N-Benzyl-N'-[1-phenyl-meth-(E)-ylidene]-N-(3-{[1-phenyl-meth-(E)-ylidene]-amino}-propyl)-propane-1,3-diamine 
• 164913-26-2 N¹,N⁹-dibenzyl-N⁵,N¹³-ditosyl-1,5,9,13-tetraazacyclohexadecane 
• 47771-56-2 N⁴-benzyl-N¹,N⁷-ditosyl-4-aza-1,7-heptanediamine 
• 1555-71-1 N1-(3-amino-propyl)-N1-benzyl-propane-1,3-diamine 

Relevant academic research and scientific papers

Unequivocal synthesis of 1,9-dibenzyl-1,5,9,13-tetracydohexadecane

Condensation of two N-benzylated derivatives 3 and 4 according to the Richman and Atkins's method allows the unequivocal synthesis of 1,9-dibenzyl-1,5,9,13-tetracyclohexadecane (2). Preparation of the two precursors 3 and 4 is also described.

Artemisinin derivative and intermediate, and preparation methods and applications thereof

The invention discloses an artemisinin derivative with a structure represented by a general formula (I), and a preparation method of the artemisinin derivative and application of the artemisinin derivative in preparation of antimalarial drugs, and further discloses an intermediate for preparing the artemisinin derivative and preparation of the intermediate.

Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders

This invention provides novel radiopharmaceuticals that are radiolabeled cyclic compounds containing carbocyclic or heterocyclic ring systems which act as antagonists of the platelet glycoprotein IIb/IIIa complex; to methods of using said radiopharmaceuticals as imaging agents for the diagnosis of arterial and venous thrombi; to novel reagents for the preparation of said radiopharmaceuticals; and to kits comprising said reagents.

Syntheses of a Series of Linear Pentaamines with Three and Four Methylene Chain Intervals

Ten kinds of linear pentaamines with various combinations of 3 or 4 methylene chain intervals were synthesized.The methods were tentatively classified into two, leading to symmetrical and unsymmetrical pentaamines, all of which were prepared by succesive alkylation of secondary amino derivatives of benzylamine with N-(3-bromopropyl or 4-bromobutyl)phthalimide in the presence of KF-Celite, coupled with the purification of the phthaloyl compounds by silica gel column chromatography.Protecting benzyl and phthaloyl groups were removed by usual methods.The carbon-13 nuclear magnetic resonance (13C-NMR) spectra ot the ten pentaamines were recorded in D2O as fully protonated forms, and a comparative analysis of their spectra allowed the complete assignment of all 13C chemical shifts.Keywords-polyamine; pentaamine; benzylamine; N-(3-bromopropyl)phthalimide; N-(4-bromobutyl)phthalimide; alkylation; potassium fluoride-Celite; 13C-NMR spectrum