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N1-(3-AMINO-PROPYL)-N1-BENZYL-PROPANE-1,3-DIAMINE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

1555-71-1

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1555-71-1 Usage

Synthesis Reference(s)

Synthesis, p. 782, 1984 DOI: 10.1055/s-1984-30973

Check Digit Verification of cas no

The CAS Registry Mumber 1555-71-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,5,5 and 5 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1555-71:
(6*1)+(5*5)+(4*5)+(3*5)+(2*7)+(1*1)=81
81 % 10 = 1
So 1555-71-1 is a valid CAS Registry Number.

1555-71-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name N'-(3-aminopropyl)-N'-benzylpropane-1,3-diamine

1.2 Other means of identification

Product number -
Other names 4-benzyl-1,7-diamino-4-azaheptane

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1555-71-1 SDS

1555-71-1Relevant academic research and scientific papers

Artemisinin derivative and intermediate, and preparation methods and applications thereof

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Paragraph 0140-0142; 0147-0149, (2020/08/18)

The invention discloses an artemisinin derivative with a structure represented by a general formula (I), and a preparation method of the artemisinin derivative and application of the artemisinin derivative in preparation of antimalarial drugs, and further discloses an intermediate for preparing the artemisinin derivative and preparation of the intermediate.

Bis-imine primary amine protection of the dialkyltriamine, norspermidine

Culf, Adrian S.,Melanson, Jennifer A.,Ouellette, Rodney J.,Briand, Glen G.

, p. 3301 - 3304 (2012/07/31)

This Letter details the particular use of salicylaldehyde (2-hydroxybenzaldehyde) for the regiospecific protection of primary amines in a representative polyamine, norspermidine (N-(3-aminopropyl)propane-1,3-diamine) under mild reaction conditions in high

Unsymmetrical cyclotriazadisulfonamide (CADA) compounds as human CD4 receptor down-modulating agents

Demillo, Violeta G.,Goulinet-Mateo, Florian,Kim, Jessica,Schols, Dominique,Vermeire, Kurt,Bell, Thomas W.

, p. 5712 - 5721 (2011/10/08)

Cyclotriazadisulfonamide (CADA) inhibits HIV at submicromolar levels by specifically down-modulating cell-surface and intracellular CD4. The specific biomolecular target of CADA compounds is unknown, but previous studies led to an unsymmetrical binding model. To test this model, methods were developed for effective synthesis of diverse, unsymmetrical CADA compounds. A total of 13 new, unsymmetrical target compounds were synthesized, as well as one symmetrical analogue. The new compounds display a wide range of potency for CD4 down-modulation in CHO-CD4-YFP cells. VGD020 (IC50 = 46 nM) is the most potent CADA compound discovered to date, and VGD029 (IC50 = 730 nM) is the most potent fluorescent analogue. Structure-activity relationships are analyzed from the standpoint of additive or nonadditive energy effects of different substituents. They appear to be consistent with the zipper-type mechanism in which entropy costs are reduced for additional stabilizing interactions between the small molecule and its protein target.

Convergent synthesis of polynitrile and/or polyamine dendrimers through hydroaminomethylation and Michael addition

Beigi, Maryam,Ricken, Stefan,Mueller, Kai Sven,Koc, Fikret,Eilbracht, Peter

supporting information; experimental part, p. 1482 - 1492 (2011/04/22)

A general concept for a versatile convergent synthesis ofpolynitrile and/or polyamine dendrimers has been developed by applying Voegtle's procedure in combination with thetandem hydroformylation/reductive amination sequence, known as hydroaminomethylation

POLYAMINE DERIVATIVE AND POLYOL DERIVATIVE

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Page/Page column 33, (2008/06/13)

A novel polyamine derivative, or polyol derivative, having a piperidylaminotriazine skeleton, salts of such compounds, a process for producing them, an organic material stabilizer comprising any of such compounds, a method of stabilizing an organic materi

Synthesis and structure-activity relationship studies of CD4 down-modulating cyclotriazadisulfonamide (CADA) analogues

Bell, Thomas W.,Anugu, Sreenivasa,Bailey, Patrick,Catalano, Vincent J.,Dey, Kaka,Drew, Michael G. B.,Duffy, Noah H.,Jin, Qi,Samala, Meinrado F.,Sodoma, Andrej,Welch, William H.,Schols, Dominique,Vermeire, Kurt

, p. 1291 - 1312 (2007/10/03)

HIV attachment via the CD4 receptor is an important target for developing novel approaches to HIV chemotherapy. Cyclotriazadisulfonamide (CADA) inhibits HIV at submicromolar levels by specifically down-modulating cell-surface and intracellular CD4. An effective five-step synthesis of CADA in 30% overall yield is reported. This synthesis has also been modified to produce more than 50 analogues. Many tail-group analogues have been made by removing the benzyl tail of CADA and replacing it with various alkyl, acyl, alkoxycarbonyl and aminocarbonyl substituents. A series of sidearm analogues, including two unsymmetrical compounds, have also been prepared by modifying the CADA synthesis, replacing the toluenesulfonyl sidearms with other sulfonyl groups. Testing 30 of these compounds in MT-4 cells shows a wide range of CD4 down-modulation potency, which correlates with ability to inhibit HIV-1. Three-dimensional quantitative structure-activity relationship (3D-QSAR) models were constructed using comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA) approaches. The X-ray crystal structures of four compounds, including CADA, show the same major conformation of the central 12-membered ring. The solid-state structure of CADA was energy minimized and used to generate the remaining 29 structures, which were similarly minimized and aligned to produce the 3D-QSAR models. Both models indicate that steric bulk of the tail group, and, to a lesser extent, the sidearms mainly determine CD4 down-modulation potency in this series of compounds.

Syntheses, conformations, and basicities of bicyclic triamines

Bell, Thomas W.,Choi, Heung-Jin,Harte, William,Drew, Michael G. B.

, p. 12196 - 12210 (2007/10/03)

The multistep syntheses of several bicyclic triamines are described, all of which have an imbedded 1,5,9-triazacyclododecane ring. In 1,5,9-triazabicyclo[7.3.3]pentadecanes 12, 13, 15, and 16, two nitrogens are bridged by three carbons. The monoprotonated forms of these triamines are highly stabilized by a hydrogen-bonded network involving the bridge and both bridgehead nitrogens, producing a difference of more than 8 pKa units in acidities of their monoprotonated and diprotonated forms. The one- and zero-carbon bridges in 1,5,9-triazabicyclo[9.1.1]tridecane (23) and 7-methyl-1,5,9-triazabicyclo[5.5.0]dodecane (39) do not enhance the stabilities of their monoprotonated forms. X-ray crystal structures and computational studies of 12·HI and 16·HI reveal similar, but somewhat weaker, hydrogen-bonded networks, relative to 15·HI. The activation free energies for conformational inversion of 13·HI (14.4 ± 0.2 kcal/mol), 16·HI (15.0 ± 0.1 kcal/mol) and 16 (8.8 ± 0.3 kcal/mol) were measured by variable-temperature 1H and 13C NMR spectroscopy. These experimental barriers give an estimate of 6.2 kcal/mol for the strength of the bifurcated hydrogen bond between the bridge nitrogen and cavity proton in 16·HI. Computational studies support the hypothesis that N-inversion occurs in an open conformation, leading to an estimate of 10.32 kcal/mol for the enthalpy of the bifurcated hydrogen bond in 16·HI in the gas phase.

Anti-viral triaza compounds and compositions

-

Page column 7, (2010/01/30)

The invention relates to a family of new synthetic triamine compounds which can be used in antiviral pharmaceutical compositions.

Unequivocal synthesis of 1,9-dibenzyl-1,5,9,13-tetracydohexadecane

Fasseur, Dominique,Lacour, Sylvie,Guilard, Roger

, p. 285 - 294 (2007/10/03)

Condensation of two N-benzylated derivatives 3 and 4 according to the Richman and Atkins's method allows the unequivocal synthesis of 1,9-dibenzyl-1,5,9,13-tetracyclohexadecane (2). Preparation of the two precursors 3 and 4 is also described.

Syntheses of a Series of Linear Pentaamines with Three and Four Methylene Chain Intervals

Niitsu, Masaru,Samejima, Keijiro

, p. 1032 - 1038 (2007/10/02)

Ten kinds of linear pentaamines with various combinations of 3 or 4 methylene chain intervals were synthesized.The methods were tentatively classified into two, leading to symmetrical and unsymmetrical pentaamines, all of which were prepared by succesive alkylation of secondary amino derivatives of benzylamine with N-(3-bromopropyl or 4-bromobutyl)phthalimide in the presence of KF-Celite, coupled with the purification of the phthaloyl compounds by silica gel column chromatography.Protecting benzyl and phthaloyl groups were removed by usual methods.The carbon-13 nuclear magnetic resonance (13C-NMR) spectra ot the ten pentaamines were recorded in D2O as fully protonated forms, and a comparative analysis of their spectra allowed the complete assignment of all 13C chemical shifts.Keywords-polyamine; pentaamine; benzylamine; N-(3-bromopropyl)phthalimide; N-(4-bromobutyl)phthalimide; alkylation; potassium fluoride-Celite; 13C-NMR spectrum

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