102210-76-4

Upstream product

• 1484-27-1 3-bromoindole 
• 98-09-9 benzenesulfonyl chloride 
• 120-72-9 indole 
• 3350-78-5 3,3-Dimethylacryloyl chloride 
• 99655-68-2 3-bromo-1-phenylsulfonyl indole 
• 40899-71-6 1-benzenesulfonylindole 
• 107-86-8 3,3-dimethyl acrylaldehyde 

Downstream Products

• 102210-78-6 1-(1-Benzenesulfonyl-1H-indol-2-yl)-3-chloro-3-methyl-butan-1-one 
• 581083-28-5 1.1-dimethyl-4-[1-(phenylsulfonyl)]-1,4-dihydrocyclopenta[b]indol-3(2H)-one 

Relevant academic research and scientific papers

HEPATITIS C INHIBITOR COMPOUNDS

Compounds of Formula (I) wherein n, X1, X2, R1, R2, Y1, Y2 and RA are defined herein, are useful for the treatment of hepatitis C viral infection.

HEPATITIS C INHIBITOR COMPOUNDS

A compound of formula (I) useful for the treatment or prevention of hepatitis C viral infection, (Formula (I)) wherein: X1 and X2 are each independently CRB or N; RB is H, (C1-6)alkyl, (C1-6/sub

Efficient synthesis of bromocyclopenta[b]indoles via a bromination - Reduction sequence

Substituted cyclopenta[b]indoles are selectively brominated in good yields with excess pyridine - Br2 charge-transfer complex (PyBr2) in a one-pot reaction to provide 5 and/or 7-bromoindoles. The mechanism involves the formation of a

Synthesis of Prenylated Indoles

Interaction of magnesium indolates and allyl oxides in the presence of bis(triphenylphosphine)nickel dichloride results in indole β-allylation, except in cases involving highly substituted indoles and allyl alcohols.This method permits the β-prenylation of indole and α-prenylation of ketones (by way of their magnesium enaminates).Base-induced interaction of ethynyldimethylcarbinyl chloride and indole under a variety of conditions yields β-(β,β-dimethylvinyl)quinoline as well as variously dehydroprenylated indoles. α-Lithiation of N-(benzenesulfonyl)indole followed by treatmentwith prenyl bromide or β,β-dimethylacrylyl chloride produces α-prenyl- or α-oxoprenylidole derivatives, the sodium amalgam reduction of the former of which yields α-prenylidole.Interaction of β-cuprated N-(benzenesulfonyl)indole with the same halides followed by reduction affords β-prenylindole and β-oxoprenylindole, the latter also being the product of the reaction of magnesium indolate and the acid chloride.Lithium aluminum hydride reduction of 1-(benzenesulfonyl)-3-oxoprenylindole affords an alcohol, whose base hydrolysis produces β-dehydroprenylindole, a compound whose dimerization has led previously to naturally occuring yuehchukene.