10222-93-2

Basic information

• Product Name: N-(tert-butyl)-3-nitrobenzamide
• Synonyms: N-(tert-butyl)-3-nitrobenzamide;N-(1,1-Dimethylethyl)-3-nitrobenzamide;N-tert-Butyl-m-nitrobenzamide
• CAS NO: 10222-93-2
• Molecular Formula: C₁₁H₁₄N₂O₃
• Molecular Weight: 222.24
• Mol File: 10222-93-2.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(tert-butyl)-3-nitrobenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(tert-butyl)-3-nitrobenzamide(10222-93-2)
• EPA Substance Registry System: N-(tert-butyl)-3-nitrobenzamide(10222-93-2)

Safety Data

• Hazardous Substances Data: 10222-93-2(Hazardous Substances Data)

Upstream product

• 645-00-1 m-iodonitrobenzene 
• 201230-82-2 carbon monoxide 
• 75-64-9 tert-butylamine 
• 121-90-4 m-nitrobenzoic acid chloride 
• 540-88-5 acetic acid tert-butyl ester 
• 619-24-9 3-nitrobenzonitrile 
• 75-65-0 tert-butyl alcohol 
• 119072-55-8 tert-butylisonitrile 
• 99-09-2 3-nitro-aniline 
• 121-92-6 3-nitrobenzoic acid 
• 586-36-7 3-nitrophenyldiazonium tetrafluoroborate 
• 585-79-5 m-nitrobromobenzene 

Downstream Products

• 645-09-0 3-nitrobenzamide 

Relevant articles and documents

The copper-catalyzed cross-coupling reactions of aryl diazonium salts and isocyanides

The copper-catalyzed cross-coupling reaction of aryl diazonium salts and isocyanides has been performed. This is a successful example of preparation of arylcarboxyamides with moderate to good yield under mild conditions.

A novel approach for the synthesis of aryl amides

A novel and highly efficient approach for the synthesis of aryl amides in high yields by the reaction of carboxylic acids and isocyanides in methanol at ambient temperature is reported.

KAl(SO4)2.12H2O as an eco-friendly and reusable catalyst for the synthesis of amides by the Ritter reaction

KAl(SO4)2.12H2O (Alum) is an eco-friendly, inexpensive, readily available and reusable and was applied as catalyst to the synthesis of N-alkyl amides from nitriles and alcohols by the Ritter reaction. This solvent-free procedure is very simple with excellent yields and easy work-up.

Catalyst-free synthesis of phenanthridinesviaelectrochemical coupling of 2-isocyanobiphenyls and amines

Catalyst free synthesis of 6-aryl phenanthridines and amides through an electrochemical reaction is reported in this study. The coupling reaction proceeds by the cathodic reduction ofin situformed diazonium ions, which are formed from anilines and an alkyl nitrite. The generated aryl radical diazonium ions coupled from isocyanides furnished the desired products in good yields. This cascade reaction was conducted in an undivided cell equipped with an RVC as the anode and Pt as the cathode usingnBu4NBF4as the electrolyte at room temperature. A series of detailed mechanistic studies have also been performed, including a radical clock experiment and cyclic voltammetry analysis.

Cp?CoIII-Catalyzed syn-Selective C-H Hydroarylation of Alkynes Using Benzamides: An Approach Toward Highly Conjugated Organic Frameworks

Hydroarylation of internal alkynes by cost-effective CoIII-catalysis, directed by N-tert-butyl amides, is achieved to avail mono- or dihydroarylated amide products selectively in an atom and step economic way. Several important functional groups were tolerated under the reaction conditions, and syn-hydroarylation products were exclusively isolated. Notably, a 4-fold C-H hydroarylation provided a highly conjugated organic framework in one step. Kinetic study with extensive deuterium labeling experiments were performed to support the proposed mechanism.