102292-67-1

Upstream product

• 109065-80-7 2,5-anhydro-3,4,6-tri-O-benzyl-1-deoxy-1-iodo-D-mannitol 
• 122-52-1 triethyl phosphite 
• 1660-94-2 Tetraethyl methylenediphosphonate 
• 68774-48-1 2,5-anhydro-1-O-trityl-D-mannitol 
• 102208-55-9 2,5-anhydro-3,4,6-tri-O-benzyl-D-mannitol 
• 160549-10-0 2,3,5-tri-O-benzyl-D-arabinofuranose 
• 115149-92-3 [(E)-(3R,4S,5R)-3,4,6-Tris-benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-hex-1-enyl]-phosphonic acid diethyl ester 
• 41107-82-8 2,5-anhydro-D-mannitol 
• 102208-53-7 (3R,4R,5R)-5-hydroxy-3,4,6-tribenzyloxy-1-hexene 
• 115214-48-7 2,3,5-tri-O-benzyl-4-O-(tert-butyldimethylsilyl)-D-arabinose ethylene dithioacetal 
• 115149-93-4 (2R,3R,4S)-1,3,4-Tris-benzyloxy-4-[1,3]dithian-2-yl-butan-2-ol 
• 102093-90-3 ((1R,2S,3R)-2,3-Bis-benzyloxy-1-benzyloxymethyl-pent-4-enyloxy)-tert-butyl-dimethyl-silane 
• 78009-77-5 2,3,5-tri-O-benzyl-4-O-(tert-butyldimethylsilyl)-aldehydo-D-arabinose 

Downstream Products

• 130372-43-9 Acetic acid (2R,3R,4S,5S)-3,4-bis-benzyloxy-5-(diethoxy-phosphorylmethyl)-tetrahydro-furan-2-ylmethyl ester 
• 130466-42-1 2,5-anhydro-3,4-di-O-benzyl-1-deoxy-1-diethylphosphono-6-O-diphenylphosphono-D-mannitol 
• 130465-01-9 ((2S,3S,4R,5R)-3,4-Bis-benzyloxy-5-hydroxymethyl-tetrahydro-furan-2-ylmethyl)-phosphonic acid diethyl ester 

Relevant academic research and scientific papers

Stereospecific synthesis of 5-phospho-α-D-arabinosyl-C-phosphonophosphate (pACpp): A stable analogue of the putative mycobacterial cell wall biosynthetic intermediate 5-phospho-D-arabinosyl pyrophosphate (pApp)

The stereospecific synthesis of 5-phospho-α-D-arabinosyl-C-phosphonophosphate (pACpp) from D-glucosamine is described. This compound was evaluated for its ability to serve as a stable analogue of the putative mycobacterial cell wall biosynthetic intermediate 5-phospho-D-arabinosyl pyrophosphate (pApp). The phosphonophosphate proved incapable of interfering with formation of the mycobacterial arabinan precursor decaprenylphospho-arabinose (DpA) in vitro.

SYNTHESIS OF C-ARABINOFURANOSYL COMPOUNDS. PHOSPHONATE AND CARBOXYLATE ISOESTERS OF D-ARABINOSE 1,5-BISPHOSPHATE

Electrophile-mediated cyclization of 3,4,6-tri-O-benzyl-1,2-dideoxy-D-arabino-hex-1-enitol with N-bromosuccinimide yielded primarily 2,5-anhydro-3,4,6-tri-O-benzyl-1-bromo-1-deoxy-D-glucitol (10).This apparently kinetically controlled reaction was of key