1024-64-2

Usage

Uses

Used in Organic Chemistry:
(2-methylphenyl)(2,4,6-trimethylphenyl)methanone is used as a building block for the synthesis of various pharmaceuticals and agrochemicals due to its unique structure and reactivity.
Used in Production of Other Organic Compounds:
(2-methylphenyl)(2,4,6-trimethylphenyl)methanone is used as a reagent in the production of other organic compounds, contributing to the synthesis of a wide range of chemical products.
Used in Drug Discovery Research:
(2-methylphenyl)(2,4,6-trimethylphenyl)methanone is studied for its potential biological and pharmacological activities, making it a target for drug discovery research and development.

Upstream product

• 933-88-0 ortho-toluoyl chloride 
• 108-67-8 1,3,5-trimethyl-benzene 
• 932-31-0 ortho-tolylmagnesium bromide 
• 938-18-1 mesitylene-2-carboxylic acid chloride 
• 615-37-2 ortho-methylphenyl iodide 
• 201230-82-2 carbon monoxide 
• 5980-97-2 mesitylboronic acid 
• 4028-63-1 iodomesitylene 
• 16419-60-6 2-Methylphenylboronic acid 
• 487-68-3 mesytaldehyde 
• 68971-87-9 (2-tolyl)tributyltin 
• 118-90-1 ortho-methylbenzoic acid 
• 13630-19-8 2-methylbenzotrifluoride 
• 89-71-4 2-Methyl-benzoic acid methyl ester 

Downstream Products

• 21945-77-7 2,4,6,2'-Tetramethyl-benzhydrol 
• 101787-43-3 methyl-(2,4,6,2'-tetramethyl-benzhydryl)-ether 
• 143617-11-2 Mesityl-o-tolyl-methanol 

Relevant academic research and scientific papers

Synthesis of Diverse Aromatic Ketones through C?F Cleavage of Trifluoromethyl Group

An efficient synthetic method of aromatic ketones through C?F cleavage of trifluoromethyl group is disclosed. The high functional group tolerance of the transformation and the remarkable stability of trifluoromethyl group in various reactions enabled mult

Iodine Promoted Conversion of Esters to Nitriles and Ketones under Metal-Free Conditions

We report a novel strategy to prepare valuable nitriles and ketones through the conversion of esters under metal-free conditions. By using the I2/PCl3 system, various substrates including aliphatic and aromatic esters could react with acetonitrile and arenes to afford the desired products in good to excellent yields. This method is compatible with a number of functional groups and provides a simple and practical approach for the synthesis of nitrile compounds and aryl ketones.

Sterically Hindered Ketones via Palladium-Catalyzed Suzuki-Miyaura Cross-Coupling of Amides by N-C(O) Activation

Herein, we report a new protocol for the synthesis of sterically hindered ketones that proceeds via palladium-catalyzed Suzuki-Miyaura cross-coupling of unconventional amide electrophiles by selective N-C(O) activation. Mechanistic studies demonstrate that steric bulk on the amide has a major impact, which is opposite to the traditional Suzuki-Miyaura cross-coupling of sterically hindered aryl halides. Structural and computational studies provide insight into ground-state distortion of sterically hindered amides and show that ortho-substitution alleviates the N-C(O) bond twist.

Erbium trifluoromethanesulfonate catalyzed Friedel-Crafts acylation using aromatic carboxylic acids as acylating agents under monomode-microwave irradiation

Erbium trifluoromethanesulfonate is found to be a good catalyst for the Friedel-Crafts acylation of arenes containing electron-donating substituents using aromatic carboxylic acids as the acylating agents under microwave irradiation. An effective, rapid and waste-free method allows the preparation of a wide range of aryl ketones in good yields and in short reaction times with minimum amounts of waste.

Selective synthetic routes to sterically hindered unsymmetrical diaryl ketones via arylstannanes

Bulky arylstannanes and bulky aroyl chlorides are good reaction partners for the synthesis of two-, three-, and even four-ortho-substituted benzophenones, in good to excellent isolated yields (47-91%). Three simple and direct routes, with differential advantages, are proposed: (i) a catalyst-free protocol, in o-dichlorobenzene (ODCB) at 180 °C; (ii) a room temperature protocol, using AlCl3 (0.5 equiv), in dichloromethane (DCM); and (iii) a solvent-free, indium-promoted procedure. A radical mechanism is proposed for the indium-mediated reactions.2011 American Chemical Society.

Sterically hindered benzophenones via rhodium-catalyzed oxidative arylation of aldehydes

(Chemical Equation Presented) Efficient cross-coupling, allowing a straightforward access to congested benzophenones, between aromatic aldehydes and potassium aryltrifluoroborates, is described in the presence of a rhodium/tri-tert-butylphosphane catalyst system and acetone as cosolvent. The use of the stable phosphonium salts of tri-tert-butylphosphane prevented the use of highly oxidizable tri-tert-butylphosphane and allowed a careful control of the stoichiometry with the rhodium.

Palladium-Catalyzed Carbonylative Cross-Coupling Reaction of Arylboronic Acids with Aryl Electrophiles: Synthesis of Biaryl Ketones

The carbonylative cross-coupling reaction of arylboronic acids with aryl electrophiles (ArI, ArBr, and ArOTf) to yield unsymmetrical biaryl ketones was carried out in anisole at 80°C in the presence of a palladium catalyst and a base. The reaction selectively proceeded under an atmospheric pressure of carbon monoxide when PdCl2(PPh3)2 (3 mol %)/K2CO3 (3 equiv) were used for aryl iodides and PdCl2(dppf) (3 mol %)/K2CO3 (3 equiv)/KI (3 equiv) for the bromides or the triflates. The carbonylation of arylboronic acids with benzyl halides gave aryl benzyl ketones.

Synthesis of unsymmetrical biaryl ketones via palladium-catalyzed carbonylative cross-coupling reaction of arylboronic acids with iodoarenes

The cross-coupling reaction between arylboronic acids, carbon monoxide (1 atm), and aryl iodides in the presence of palladium catalyst and base provided unsymmetrical biaryl ketones in high yields. The choice of a suitable base and solvent was essential to achieve selective formation of the unsymmetrical biaryl ketone without a biaryl by-product.