102459-17-6Relevant academic research and scientific papers
Stereoselective synthesis of trisubstituted alkenes via cobalt-catalyzed double dehydrogenative borylations of 1-alkenes
Wen, Huanan,Zhang, Lei,Zhu, Suzhen,Liu, Guixia,Huang, Zheng
, p. 6419 - 6425 (2017)
A highly selective cobalt-catalyzed single and double dehydrogenative borylations (DHBs) of terminal alkenes have been developed for the synthesis of trans-monoborylalkenes and diborylalkenes, respectively. While the cobalt-catalyzed double DHBs of aryl 1
A decarboxylative approach for regioselective hydroarylation of alkynes
Zhang, Jing,Shrestha, Ruja,Hartwig, John F.,Zhao, Pinjing
, p. 1144 - 1151 (2016/11/28)
Regioselective activation of aromatic C-H bonds is a long-standing challenge for arene functionalization reactions such as the hydroarylation of alkynes. One possible solution is to employ a removable directing group that activates one of several aromatic C-H bonds. Here we report a new catalytic method for regioselective alkyne hydroarylation with benzoic acid derivatives during which the carboxylate functionality directs the alkyne to the ortho-C-H bond with elimination in situ to form a vinylarene product. The decarboxylation stage of this tandem sequence is envisioned to proceed with the assistance of an ortho-alkenyl moiety, which is formed by the initial alkyne coupling. This ruthenium-catalysed decarboxylative alkyne hydroarylation eliminates the common need for pre-existing ortho-substitution on benzoic acids for substrate activation, proceeds under redox-neutral and relatively mild conditions, and tolerates a broad range of synthetically useful aromatic functionality. Thus, it significantly increases the synthetic utility of benzoic acids as easily accessible aromatic building blocks.
