102473-43-8

Basic information

• Product Name: Toluene-4-sulfonic acid (R)-3-cyclohexyl-3-hydroxy-3-phenyl-propyl ester
• CAS NO: 102473-43-8
• Molecular Weight: 388.528
• Mol File: 102473-43-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Toluene-4-sulfonic acid (R)-3-cyclohexyl-3-hydroxy-3-phenyl-propyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Toluene-4-sulfonic acid (R)-3-cyclohexyl-3-hydroxy-3-phenyl-propyl ester(102473-43-8)
• EPA Substance Registry System: Toluene-4-sulfonic acid (R)-3-cyclohexyl-3-hydroxy-3-phenyl-propyl ester(102473-43-8)

Safety Data

• Hazardous Substances Data: 102473-43-8(Hazardous Substances Data)

Upstream product

• 135033-55-5 (2R)-Benzoyl-3-oxa-1-azabicyclo<3.3.0>octane 
• 135033-59-9 (R)-Cyclohexyl-phenyl-(3R,7aS)-tetrahydro-pyrrolo[1,2-c]oxazol-3-yl-methanol 
• 149597-98-8 (R)-(-)-1-cyclohexyl-1-phenyl-1,3-propanediol 
• 98-59-9 p-toluenesulfonyl chloride 
• 135033-59-9 (S)-Cyclohexyl-phenyl-(3R,7aS)-tetrahydro-pyrrolo[1,2-c]oxazol-3-yl-methanol 
• 114499-81-9 (S)-(+)-1-cyclohexyl-1-phenyl-1,3-propanediol 
• 20585-37-9 (R)-(-)-2-Cyclohexyl-2-hydroxy-2-phenyl-acetaldehyd 
• 149714-31-8 (R)-(-)-1-cyclohexyl-1-phenyl-2-propen-1-ol 
• 10074-42-7 cyclohexyllithium 
• 1075-06-5 2,2-dihydroxy-1-phenyl-ethanone 
• 20585-32-4 (S)-(+)-2-cyclohexyl-2-hydroxy-2-phenylacetaldehyde 
• 135033-61-3 (S)-(+)-1-cyclohexyl-1-phenyl-2-propen-1-ol 
• 108667-55-6 1-cyclohexyl-1-phenylpropane-1,3-diol 

Downstream Products

• 40520-25-0 (-)-Trihexyphenidyl 
• 40520-24-9 (+)-Trihexyphenidyl 
• 115-64-0 1-cyclohexyl-3-diethylamino-1-phenyl-propan-1-ol 
• 119483-34-0 (+/-)-1-(3-cyclohexyl-3-hydroxy-3-phenyl-propyl)-1-methyl-pyrrolidinium; toluene-4-sulfonate 

Relevant articles and documents

Stereodivergent synthesis of optically active tertiary alcohols via addition reaction of chiral 2-acyl oxazolidine with organometallics

It was observed that diastereoselectivity in an addition reaction to chiral 2-acyl oxazolidine, derived from (S)-prolinol, can be fully regulated under appropriate conditions. Addition of organotitanium triisopropoxides provided (S)-tertiary alcohols, while organolithium reagents afforded the corresponding (R)-alcohols. Application of this methodology was demonstrated in the synthesis of (+)- and (-)-trihexyphenidyl.