1025-75-8

Basic information

• Product Name: 6-chloro-3-methyl-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
• Synonyms: Hydrochlorothiazide Impurity G
• CAS NO: 1025-75-8
• Molecular Formula: C₈H₈ClN₃O₄S₂
• Molecular Weight: 309.7498
• Mol File: 1025-75-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 594.3°C at 760 mmHg
• Flash Point: 313.2°C
• Density: 1.93g/cm³
• Vapor Pressure: 4.29E-14mmHg at 25°C
• Refractive Index: 1.768
• CAS DataBase Reference: 6-chloro-3-methyl-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-3-methyl-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide(1025-75-8)
• EPA Substance Registry System: 6-chloro-3-methyl-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide(1025-75-8)

Safety Data

• Hazardous Substances Data: 1025-75-8(Hazardous Substances Data)

Usage

General Description

6-Chloro-3-methyl-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide is a chemical compound that belongs to the class of benzothiadiazine sulfonamide derivatives. It is often used as a diuretic in the treatment of high blood pressure and fluid retention. 6-chloro-3-methyl-4H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide works by inhibiting the reabsorption of sodium in the kidneys, leading to increased excretion of water and salt from the body. It is commonly found in pharmaceutical drugs, where it is used to help regulate blood pressure and reduce edema. Additionally, it may have other potential applications in medicinal chemistry and drug development due to its unique chemical structure and pharmacological properties.

Upstream product

• 1029-80-7 N-Acetyl-5-chlor-anilin-disulfonsaeure-(2.4)-dichlorid 
• 121-30-2 chloraminophenamide 
• 75-07-0 acetaldehyde 
• 64-19-7 acetic acid 
• 100191-64-8 4-acetylamino-6-chloro-benzene-1,3-disulfonyl chloride 

Relevant articles and documents

Synthesis, characterization, and investigation of the antioxidant activity of some 1,2,4-benzothiadiazine-1,1-dioxides bearing sulfonylthioureas moieties

A series of 1,2,4-benzothiadiazine-1,1-dioxides bearing a sulfonylthiourea moiety were synthesized, characterized, and screened for their antioxidant activity, using six antioxidant analytical assays comparatively to reference compounds, ascorbic acid and quercetin. The results indicated that several compounds demonstrated strong antioxidant activity in DPPH, ABTS, H2O2, and lipid peroxidation assays where some of them were either as active as or more active than reference compounds. However, all compounds were largely less active than references compounds in the reducing power assay. The results indicated that the thiourea moiety probably played a crucial role in the antioxidant activity of the target compounds, as a thiolate ion. The most favorable R1 groups were the hydrogen atom and methyl group, followed by phenyl and benzyl groups, whereas the most favorable R2 group was iPr, followed by the phenyl and methyl groups. The combination of benzothiadiazine ring with sulfonylthiourea moieties led to valuable new antioxidants, which could be used in the treatment or the prevention of certain diseases or in the field of cosmetics, which needs further investigations in the future.