10256-00-5

Usage

InChI:InChI=1/C15H26N2O2/c18-14(16-12-7-3-1-4-8-12)11-15(19)17-13-9-5-2-6-10-13/h12-13H,1-11H2,(H,16,18)(H,17,19)

Upstream product

• 108-91-8 cyclohexylamine 
• 105-53-3 diethyl malonate 
• 73453-43-7 Ethyl Acetyl-N-cyclohexylmalonamate 
• 111-27-3 hexan-1-ol 
• 3173-53-3 Cyclohexyl isocyanate 
• 73453-46-0 Acetyl-N,N'-dicyclohexylmalonamide 
• 49754-15-6 malonyldiurethane 

Downstream Products

• 54535-29-4 1-cyclohexyl-2,4,5-trioxo-pyrrolidine-3-carboxylic acid cyclohexylamide 
• 13381-09-4 1,1,3,3-Tetrakis-cyclohexylcarbamoyl-propan 

Relevant academic research and scientific papers

N,N'-Disubstituted Dithiomalonamide Complexes of Antimony(III). Crystal and Molecular Structure of with Lone-pair Occupation of an Antimony Co-ordination Site

Direct addition of antimony(III) trichloride to N,N'-disubstituted dithiomalonamides, RHNC(S)CH2C(S)NHR (R = CH3, C2H5, i-C3H7, n-C4H9, or cyclo-C6H11), gives rise to 1:1 complexes.I.r. and n.m.r. data suggest that the complexes have equivalent structures

Reactions of Acetoacetic Ester Blocked Cyclohexyl Isocyanate

Acetoacetic ester has been widely reported to be a blocking agent for isocyanates.However, we find that only a trace of isocyanate is formed by thermolysis of acetoacetic ester blocked cyclohexyl isocyanate, 1, at 150 deg C and atmospheric pressure.The major portion is unchanged even after 8 h, with some conversion to acetylmalonic ester, 2, and acetyl-N,N'-dicyclohexylmalonamide, 3.Alcoholysis does not yield the "normal" urethane as blocked isocyanates do but rather esters of 1 with some diesters of 2 and smaller amounts of 3.Significant amounts of N-cyclohexylacetamide, N-cyclohexylmalonamate ester, and some N,N'-dicyclohexylmalonamide are also obtained.Aminolysis leads to N-substituted acetamides and N-cyclohexylmalonamate but no substituted ureas, the "normal" products for aminolysis of blocked isocyanates.In the presence of acid catalysts, alcoholysis leads to N-cyclohexylmalonamates with acetate esters as the other product.

New derivatives of oxazolidinedione and pyrrolidinetrione as potential antiinflammatory agents

Syntheses of new derivatives of oxazolidinedione and pyrrolidinetrione as potential antiinflammatory agents are described. Dicyclohexylsuccindiamide and dicyclohexylmalondiamide when condensed with oxalyl dichloride afforded ethanediylidenebis (3 cyclohexyloxazolidine 4,5 dione) (I) and 1 cyclohexyl 2,4,5 trioxopyrrolidine 3 N cyclohexylcarboxamide (IX), respectively. Compound (I) when treated with sodium ethoxide isomerized to 4,4 bi [1 cyclohexyl 2,3,5 trioxopyrrolidinyl] (II). N Cyclohexylacetamide and oxalyl dichloride gave 2 methylene 3 cyclohexyloxazolidine 4,5 dione (IV) which was obtained also on condensing sodium N cyclohexylacetamide enolate with oxalyl dichloride. Compound (IV) when treated with sodium ethoxide afforded 1 cyclohexyl 3 (1 cyclohexylpyrrolidine 2,3,5 trione 4 ylidenyl)pyrrolidine 2,5 dione 3 ylidene (VIII) which was synthesized also by condensing cyclohexylamine with diethyl oxalacetate in the presence of sodium ethoxide or from N cyclohexylacetamide and ethyl oxalate. Pharmacologic testing revealed strong antiinflammatory activity of compound III (the sodium derivative of II) and of IV and IX whereas the other compounds showed low absorption and were not further examined.