1025865-31-9

Upstream product

• 109888-65-5 3-(4-trifluoromethylphenyl)-4,5-dihydroisoxazole-5-carboxylic acid 
• 886967-65-3 ethyl 3-(4-trifluoromethylphenyl)-4,5-dihydroisoxazole-5-carboxylate 
• 74467-05-3 N-hydroxy-4-(trifluoromethyl)benzenecarboximidoyl chloride 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 66046-34-2 4-(trifluoromethyl)benzaldehyde oxime 

Downstream Products

• 501919-08-0 3-(4-trifluoromethylphenyl)isoxazole 
• 1235471-32-5 4,5-dihydro-3-[4-(trifluoromethyl)phenyl]isoxazole-5-carboxylic acid 3,5-dichloro-2,6-difluoropyridin-4-ylamide 

Relevant academic research and scientific papers

Synthesis and biological activity of 3-substituted isoxazolecarboxamides

A series of novel 3-substituted isoxazolecarboxamides have been prepared. A key step was 1,3-dipolar cycloaddition of nitrile oxides to α,β-unsaturated esters. Some of these compounds exhibited high fungicidal activities against Alternaria alternata, Botrytis cinerea, Rhizoctonia solani, Fusarium culmorum, and Phytophthora cactorum.

New fragmentation of 2-isoxazoline-5-carboxylic acid chlorides

A novel base promoted degradation of 3-aryl-2-isoxazoline-5-carboxylic acid chlorides to aryl nitriles has been discovered.