109888-65-5Relevant academic research and scientific papers
Synthesis and biological activity of 3-substituted isoxazolecarboxamides
Gucma, Miroslaw,Golebiewski, W. Marek
scheme or table, p. 461 - 469 (2011/07/30)
A series of novel 3-substituted isoxazolecarboxamides have been prepared. A key step was 1,3-dipolar cycloaddition of nitrile oxides to α,β-unsaturated esters. Some of these compounds exhibited high fungicidal activities against Alternaria alternata, Botrytis cinerea, Rhizoctonia solani, Fusarium culmorum, and Phytophthora cactorum.
Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial
Varshney, Vandana,Mishra, Nripendra N.,Shukla, Praveen K.,Sahu, Devi P.
scheme or table, p. 3573 - 3576 (2010/03/31)
A series of (5S) N-(3-{3-fluoro-4-[4-(3-aryl-4,5-dihydro-isoxazole-5-carbonyl)-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-ylmethyl)-acetamide(6a-o) were synthesized and their in vitro antibacterial activity against various resistant Gram-positive and Gram-negative bacteria were evaluated. Most of the synthesized compounds showed 2 to 10 fold lower MIC values compared to linezolid against Staphylococcus aureus ATCC 25923, ATCC 70069, ATCC 29213, Bacillus cereus MTCC 430, Enterococcus faecalis MTCC439, Klebsiella pneumoniae ATCC 27736, and Streptococcus pyogens.
New fragmentation of 2-isoxazoline-5-carboxylic acid chlorides
Golebiewski,Gucma
, p. 509 - 513 (2007/10/03)
A novel base promoted degradation of 3-aryl-2-isoxazoline-5-carboxylic acid chlorides to aryl nitriles has been discovered.
Isoxazoline derivatives and plant growth regulators
-
, (2008/06/13)
Novel 3-substituted phenyl-2-isoxazoline-5-carboxylic acids or esters thereof. These compounds have excellent properties as plant growth regulators.
