1025995-08-7

Upstream product

• 102-09-0 bis(phenyl) carbonate 
• 873843-76-6 (R)-3-(2-bromo-4-methoxyphenyl)-2-(methylamino)propan-1-ol 
• 873843-75-5 [(R)-2-(2-bromo-4-methoxyphenyl)-1-hydroxymethylethyl]-carbamic acid tert-butyl ester 
• 873843-74-4 (R)-3-(2-bromo-4-methoxyphenyl)-2-tert-butoxycarbonylaminopropionic acid methyl ester 
• 873843-73-3 (Z)-3-(2-bromo-4-methoxyphenyl)-2-tert-butoxycarbonylaminoacrylic acid methyl ester 
• 1026299-19-3 C₁₁H₁₂BrNO₃ 
• 74-88-4 methyl iodide 
• 43192-31-0 2-bromo-4-methoxybenzaldehyde 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 873843-76-6 (R)-3-(2-bromo-4-methoxyphenyl)-2-(methylamino)propan-1-ol 
• 925452-26-2 C₁₁H₁₄BrNO₃S 
• 873843-72-2 (R)-4-(2-bromo-4-methoxybenzyl)-3-methyl-1,2,3-oxathiazolidine 2,2-dioxide 

Relevant academic research and scientific papers

An asymmetric approach towards (-)-aphanorphine and its analogues

A short enantioselective approach towards the alkaloid (-)-aphanorphine and its substituted analogues is described. The enantiomerically pure starting material for the synthesis was obtained by asymmetric hydrogenation in the presence of the Rh-(S)-PipPho

Cyclic sulfamidates as versatile lactam precursors. An evaluation of synthetic strategies towards (-)-aphanorphine

A full account of studies which led to the efficient asymmetric synthesis of (-)-aphanorphine 1 is reported. Two routes to the key cyclic sulfamidate intermediate 5 are described, the first was based on a chiral auxiliary approach and the second utilised

Cyclic sulfamidates as lactam precursors. An efficient asymmetric synthesis of (-)-aphanorphine

A short and efficient enantioselective synthesis of (-)-aphanorphine is described based on the use of a cyclic sulfamidate to provide a suitably functionalised lactam that allows for construction of the tricyclic 3-benzazepine scaffold. The Royal Society