10264-10-5

Upstream product

• 100-46-9 benzylamine 
• 645-45-4 hydrocinnamic acid chloride 
• 3538-68-9 3-phenylpropanehydrazide 
• 83421-80-1 3-phenylpropanoyl azide 
• 64-04-0 phenethylamine 
• 501-52-0 3-Phenylpropionic acid 
• 87377-86-4 4-Nitro-1-phenyl-hexan-3-one 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 100-42-5 styrene 
• 6343-54-0 N-benzylformamide 
• 2021-28-5 ethyl dihydrocinnamate 
• 14371-10-9 (E)-3-phenylpropenal 
• 19261-37-1 2-chloro-3-phenyl-propionaldehyde 
• 31508-44-8 2-phenylpropionic acid methyl ester 

Downstream Products

• 2021-28-5 ethyl dihydrocinnamate 
• 180896-96-2 (4R)-2-(2-phenyl)ethyl-thiazoline-4-carboxylic acid ethyl ester 
• 25478-36-8 2-phenethyl-4,5-dihydro-thiazole 
• 32861-51-1 benzyl-(3-phenyl-propyl)-amine 
• 1384953-93-8 C₂₀H₂₉NSi 
• 122-97-4 3-Phenyl-1-propanol 
• 101023-15-8 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl 3-phenylpropionate 

Relevant academic research and scientific papers

First synthesis of non-symmetrical "phthalimidoyl active ester" bi-dentate cross-linking reagents having an acid chloride, 2-benzothiazole, or 1-benzotriazol group

For the purpose of modification of a variety of derivatives, including biologically important compounds, such as sugar derivatives and proteins etc., we have first synthesized several non-symmetrical bi-dentate cross-linking reagents, namely 3-(phthalimidoyloxycarbonyl)butyric acid chloride (1), 4-(2-benzothiazolyloxycarbonyl)butyric-N-hydroxyphthalimide ester (4) and 4-(1-benzotriazoleoxa)butyric-N-hydroxyphthalimide ester (5).

Rhodium-Catalyzed Asymmetric Synthesis of β-Branched Amides

A general asymmetric route for the one-step synthesis of chiral β-branched amides is reported through the highly enantioselective isomerization of allylamines, followed by enamine exchange, and subsequent oxidation. The enamine exchange allows for a rapid and modular synthesis of various amides, including challenging β-diaryl and β-cyclic.

Size of gold nanoparticles driving selective amide synthesis through aerobic condensation of aldehydes and amines

Metal nanoparticles (NPs) have attracted much attention in many fields due to their intrinsic characteristics. It is generally accepted that smaller NPs (1.5-3 nm) are more active than larger NPs, and reverse cases are very rare. We report here the direct aerobic oxidative amide synthesis from aldehydes and amines catalyzed by polymer-incarcerated gold (Au) NPs. A unique correlation between imine/amide selectivity and size of NPs was discovered; Au-NPs of medium size (4.5-11 nm) were found to be optimal. High yields were obtained with a broad range of substrates, including primary amines. Au-NPs of medium size could be recovered and reused several times without loss of activity, and they showed good activity and selectivity in amide formation from alcohols and amines. Superior activity and selectivity of gold nanoparticles (Au-NPs) of medium size (4.5-11 nm) were found for the direct and selective aerobic oxidative amide synthesis from various combinations of aldehydes and amines. This is an example of an unusual correlation between the size of NPs and their activity/selectivity. These catalysts could be recovered and reused several times without loss of activity.

An effective method for the synthesis of carboxamides by using tetrakis(pyridine-2-yloxy)silane as a mild coupling reagent

Tetrakis(pyridin-2-yloxy)silane [Si(OPy)4] is easily prepared by trans-silylation between silicon tetrachloride and trimethyl(pyridin-2-yloxy) silane in the molar ratio of 1:4. This novel reagent is effectively employed as a mild dehydrating reagent in forming various carboxamides from the corresponding carboxylic acids and amines that involve secondary or tertiary alkyl substituted ones in good to high yields without using any basic promoters such as tertiary amines or 4-(dimethylamino)pyridine. Copyright

A convenient method for the synthesis of carboxamides and thioesters by using tetrakis(2-methylimidazol-1-yl)silane

Tetrakis(2-methylimidazol-1-yl)silane [Si(2-Me-Im)4], a new dehydrating reagent having silicon-imidazole linkage, reacted readily with carboxylic acids at room temperature to form the corresponding 1-acyl-2-methylimidazole intermediates, which smoothly underwent subsequent condensation with nucleophiles such as amines or thiols to afford the corresponding carboxamides or thioesters in good to excellent yields, respectively.

Ruthenium-catalyzed oxidation of alcohols into amides

The synthesis of secondary amides from primary alcohols and amines has been developed using commercially available [Ru(p-cymene)CI2]2 with bis(diphenylphosphino)butane (dppb) as the catalyst.

The effective use of substituted benzoic anhydrides for the synthesis of carboxamides

Various carboxamides are synthesized from the corresponding carboxylic acids and amines with high product-selectivities using 2-methyl-6-nitrobenzoic or 2,4,6-trichlorobenzoic anhydride in the presence of 4-(dimethylamino) pyridine.

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride: An efficient condensing agent leading to the formation of amides and esters

4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) was quantitatively synthesized by the coupling of 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) and N- methylmorpholine (NMM) in THF, and characterized. Condensation of carboxylic acids and amines by DMTMM proceeded effectively in THF to give the corresponding amides in good yields. The corresponding esters can be obtained by esterification of carboxylic acids with DMTMM in methanol, ethanol, isopropyl alcohol, or t-butyl alcohol in the presence of NMM. The amount of alcohols can be reduced to a stoichiometric amount by conducting the reaction in THF. Since the reactions proceed under atmospheric conditions without drying of the solvent, and the co- product (4,6-dimethoxy-1,3,5-triazin-2(1H)-one) arising from DMTMM after condensation can be readily removed by extraction, this method is a very practical one.

Polymer-anchored Ru(II) complex as an efficient catalyst for the synthesis of primary amides from nitriles and of secondary amides from alcohols and amines

A polymer-anchored ruthenium(II) catalyst was synthesized and characterized. Its catalytic activity was evaluated for the preparation of primary amides from aqueous hydration of nitriles in neutral condition. A range of nitriles were successfully converted to their corresponding amides in good to excellent yields. The catalyst was also effective in the preparation of secondary amides from the coupling of alcohols and amines. The catalyst can be facilely recovered and reused six times without a significant decrease in its activity.

One-Pot Controlled Reduction of Conjugated Amides by Sequential Double Hydrosilylation Catalyzed by an Iridium(III) Metallacycle

A single and accessible cationic iridiumIII metallacycle effectively catalyzes the one-pot sequential double hydrosilylation of challenging α,β-unsaturated secondary and tertiary amides to afford, in a controlled and straightforward way, the co