10266-13-4

Upstream product

• 14752-72-8 1,N-Diphenylpropanimine 
• 138356-04-4 3-imino-1,3,N-triphenyl-2-methylprop-1-enylamine 
• 72374-63-1 N-(4-Methylphenyl)-1-phenylpropanimine 
• 62-53-3 aniline 
• 13209-38-6 (2-aminophenyl)(phenyl)methanol 
• 93-55-0 1-phenyl-propan-1-one 
• 1448363-43-6 2,4-diphenyl-3-methyl-3H-1-benzazepine 
• 538-51-2 benzylidene phenylamine 
• 1885-29-6 anthranilic acid nitrile 
• 1196-28-7 2'-Aminopropiophenon 
• 141075-44-7 3-methyl-2-phenylhydroquinolin-4-one 
• 98-80-6 phenylboronic acid 
• 100-52-7 benzaldehyde 
• 22065-57-2 ethyl 2-phenyldiazoacetate 

Downstream Products

• 88795-69-1 1-Ethyl-3-methyl-4-phenyl-1H-quinolin-2-one 

Relevant academic research and scientific papers

Catalyst free indirect Friedlaender synthesis of substituted quinolines from alcohols in PEG-400

The synthesis of substituted quinolines can be easily and greenly accomplished by the direct reaction between the corresponding aminoalcohol and ketone using PEG-400 as reaction medium in the presence of a base, without any transition-metal catalyst.

Oxidative ring-contraction of 3H-1-benzazepines to quinoline derivatives

When treated with SeO2, 2,4-diphenyl-3H-1-benzazepine (1) is oxidized equally at C3 and C5, giving either products of rearrangement or fragmentation; in both cases quinoline derivatives are the primary products. When C3 is oxidized, electrocycl

One-Pot Synthesis of 4-Quinolone via Iron-Catalyzed Oxidative Coupling of Alcohol and Methyl Arene

Herein, we describe the iron(III)-catalyzed oxidative coupling of alcohol/methyl arene with 2-amino phenyl ketone to synthesize 4-quinolone. Alcohols and methyl arenes are oxidized to the aldehyde in the presence of an iron catalyst and di-tert-butyl peroxide, followed by a tandem process, condensation with amine/Mannich-type cyclization/oxidation, to complete the 4-quinolone ring. This method tolerates various kinds of functional groups and provides a direct approach to the synthesis of 4-quinolones from less functionalized substrates.

A Tf2O-Promoted Synthesis of Functionalized Quinolines from Ketoximes and Alkynes

A new general synthesis of quinolines was developed from ketoximes and alkynes in the presence of Tf2O. It offered the first direct synthesis of quinolines by using the nitrilium salts generated in situ from a Tf2O-promoted Beckmann rearrangement of ketoximes under very easy conditions. (Figure presented.).

Highly Diastereo- And Enantioselective Ir-Catalyzed Hydrogenation of 2,3-Disubstituted Quinolines with Structurally Fine-Tuned Phosphine-Phosphoramidite Ligands

A highly diastereo- and enantioselective Ir-catalyzed hydrogenation of unfunctionalized 2,3-disubstituted quinolines, especially 3-alkyl-2-arylquinolines, has been realized. The success of this hydrogenation is ascribed to the use of a structurally fine-tuned chiral phosphine-phosphoramidite ligand with a (Sa)-3,3′-dimethyl H8-naphthyl moiety and (Rc)-1-phenylethylamine backbone. The hydrogenation displayed broad functional group tolerance, thus furnishing a wide range of optically active 2,3-disubstituted tetrahydroquinolines in up to 96% ee and with perfect cis-diastereoselectivity.

A method for utilizing the aromatic amine, aromatic aldehyde, synthesized of quinoline derivatives

The invention provides a method for synthesizing a quinoline derivative by utilizing arylamine, aromatic aldehyde and ketone, and belongs to the technical field of the synthesis of the quinoline derivative. According to the method for synthesizing a quinoline derivative by utilizing arylamine, aromatic aldehyde and ketone, in the existence of silver trifluoromethanesulfonate and trifluoromethanesulfonic acid, the quinoline derivative is synthesized by virtue of the reaction of an arylamine compound, an aromatic aldehyde compound and ketone compound. A reaction general formula is as shown in the specification. Compared with the prior art, the method is not only applicable to a great amount of functional groups, but also is simple in operation, high in yield, single in product structure, convenient to separate and purify, safe, low in price and small in pollution.

Palladium-Catalyzed [5+1] Annulation of 2-(1-Arylvinyl) Anilines and α-Diazocarbonyl Compounds toward Multi-functionalized Quinolines

A palladium-catalyzed [5+1] annulation of 2-(1-arylvinyl) anilines and α-diazocarbonyl compounds has been developed, affording a series of multi-functionalized quinolines in moderate to good yields. This procedure proceeded with the sequential insertion o

Metal free carboamination of internal alkynes - An easy access to polysubstituted quinolines

A metal free carboamination of unactivated alkynes towards highly substituted quinolines was realized in the presence of a synergistic Br?nsted acid catalyst system. Supported by mechanistic probes, the reaction proceeds via a highly reactive vinyl cation in a C-C bond formation - Schmidt reaction sequence. The irreversible extrusion of N2, as a powerful driving force, allows for a general conversion of poorly nucleophilic aliphatic alkynes.

Silver-catalyzed one-step synthesis of multiply substituted quinolines

A silver-catalyzed formation of C-C bond for the construction of a series of polysubstituted quinolines from arylamines, aldehydes, and ketones or arylamines and 1,3-diketones has been developed. The transformation is effective for a broad range of substrates, thus enabling the expansion of constituent architectures on the heterocyclic framework. This use of a single catalytic system to mediate chemical transformations in a synthetic operation is important for the development of new atom-economic strategies and this strategy is efficient in building complex structures from simple starting materials in an environmentally benign fashion.

Alkyltriflate-triggered annulation of arylisothiocyanates and alkynes leading to multiply substituted quinolines through domino electrophilic activation

The reaction of arylisothiocyanate, alkyltriflate, and alkynes leads to variously substituted quinolines in high yields. The reaction undergoes alkyltriflate-triggered domino electrophilic activation and avoids the use of a transition-metal catalyst. A variety of functional groups are tolerated in the quinoline ring.