102660-13-9

Basic information

• Product Name: Phosphonic acid, (triphenylmethyl)-, dimethyl ester
• CAS NO: 102660-13-9
• Molecular Formula: C21H21O3P
• Molecular Weight: 352.37
• Mol File: 102660-13-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, (triphenylmethyl)-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, (triphenylmethyl)-, dimethyl ester(102660-13-9)
• EPA Substance Registry System: Phosphonic acid, (triphenylmethyl)-, dimethyl ester(102660-13-9)

Safety Data

• Hazardous Substances Data: 102660-13-9(Hazardous Substances Data)

Upstream product

• 341-02-6 trityl tetrafluoroborate 
• 186581-53-3 diazomethane 
• 4759-28-8 tritylphosphonic acid 
• 596-43-0 bromo-triphenyl-methane 
• 121-45-9 phosphorous acid trimethyl ester 
• 77-78-1 dimethyl sulfate 
• 76-83-5 trityl chloride 

Downstream Products

• 92-52-4 biphenyl 
• 132205-80-2 dimethyl phosphonate 
• 62456-46-6 dimethyl 1-ethoxybenzyl phosphonate 

Relevant articles and documents

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PHOSPHOROUS CONTAINING COMPOUNDS INCLUDING TRIPHENYLMETHYLPHOSPHONATE ESTERS FOR THE TREATMENT OF MELANOMA AND OTHER CANCERS

Compounds and related methods for synthesis, and the use of compounds and combination therapies for the treatment of cancer and modulation of apoptosis in cells are disclosed. Particularly disclosed are phosphonate esters. Compounds, methods of making the compounds, medicaments and method of manufacture of medicaments and therapeutic methods with applications against cancer including breast cancer, melanoma, colon cancer, leukemia and lymphoma, and other cancer cells are described.

Photolysis of triarylmethylphosphonic acids and their esters

Upon UV-irradiation in an alkaline alcohol solution, some triarylmethylphosphonic acids underwent C-P bond cleavage to give triarylmethanes and alkyl dihydrogenphosphates, while, in an acidic or a neutral alcohol solution, they afforded biaryls. Their dimethyl esters gave also biaryls and dimethyl [alkoxy(aryl)methyl]phosphonates, which were derived from the insertion of (dialkoxyphosphinyl) arylcarbenes into the OH bond of the alcohol. The carbene was generated by photo-α,α-elimination of two aryl groups of the phosphonate.