1027077-17-3

Basic information

• Product Name: 1-[4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-4-(1H-indol-3-yl)-butan-1-one
• Synonyms: 1-[4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-4-(1H-indol-3-yl)-butan-1-one
• CAS NO: 1027077-17-3
• Molecular Weight: 362.447
• Mol File: 1027077-17-3.mol

Chemical Properties

• CAS DataBase Reference: 1-[4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-4-(1H-indol-3-yl)-butan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-4-(1H-indol-3-yl)-butan-1-one(1027077-17-3)
• EPA Substance Registry System: 1-[4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-4-(1H-indol-3-yl)-butan-1-one(1027077-17-3)

Safety Data

• Hazardous Substances Data: 1027077-17-3(Hazardous Substances Data)

Upstream product

• 133-32-4 4-indol-3-yl-butyric acid 
• 1978-61-6 4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 553631-05-3 tert-butyl 4-hydroxy-4-(4-fluorophenyl)-1-piperidinecarboxylate 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 163631-02-5 1-benzyl-4-(4-fluorophenyl)-4-hydroxypiperidine 
• 3612-20-2 1-phenylmethyl-4-piperidone 

Downstream Products

• 143682-41-1 3-{4-[4-(4-fluorophenyl)-1-(1,2,3,6-tetrahydro)pyridinyl]-1-butyl}-1H-indole 

Relevant articles and documents

Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro-1- pyridylalkyl)indoles. A novel conformational model to explain structure- activity relationships

The synthesis and dopaminergic properties of a novel type of dopamine agonist is described. The number and kind of essential structural elements differ significantly from that of the rigid apomorphine-type dopamine agonists. Using standard molecular modeling techniques, a conformational model is developed proposing a U-shaped conformation which might be energetically preferred through aromatic π-π-interactions between both of the electron rich aromatic structural elements of this class of compounds. Superimposition of conformations of the lead compound 28 with apomorphine yields a novel model explaining the atypical structure-activity relationships found in this class of indolealkylamines.