1978-61-6

Basic information

• Product Name: 4-(4-FLUOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE
• Synonyms: 4-(4-FLUOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE;1,2,3,6-tetrahydro-4-(p-fluorophenyl)-pyridinhydrochloride;4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridinehydrochloride;4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride, 99+%;4-(4-Fluorophenyl)-1,2,5,6-tetrahydropyridine Hydrochloride;Pyridine, 4-(4-fluorophenyl)-1,2,3,6-tetrahydro-, hydrochloride;4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine hydrochloride, 98+%;1-Fluoro-4-(1,2,3,6-tetrahydropyridin-4-yl)benzene hydrochloride
• CAS NO: 1978-61-6
• Molecular Formula: C₁₁H₁₂FN*ClH
• Molecular Weight: 213.68
• EINECS: 217-836-9
• Mol File: 1978-61-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 169-173 °C
• Boiling Point: 264ºC at 760 mmHg
• Flash Point: 113.4ºC
• Appearance: /
• Vapor Pressure: 0.00997mmHg at 25°C
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: DMSO (Slightly), Water (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 4-(4-FLUOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-FLUOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE(1978-61-6)
• EPA Substance Registry System: 4-(4-FLUOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE(1978-61-6)

Safety Data

• Hazard Codes: T
• Statements: 40-23/24/25
• Safety Statements: 45-38-36/37/39-28A
• Hazardous Substances Data: 1978-61-6(Hazardous Substances Data)

Usage

Chemical Properties

LIGHT YELLOW TO BEIGE POWDER

Uses

Different sources of media describe the Uses of 1978-61-6 differently. You can refer to the following data:
1. A reagent in the preparation of 4-phenyl-tetrahydrophenyl substituted oxazolidinone derivatives with potent central nervous depressant, analgetic, and antiinflammatory activities as well as α1A adrene rgic receptor antagonists.
2. A reagent in the preparation of 4-phenyl-tetrahydrophenyl substituted oxazolidinone derivatives with potent central nervous depressant, analgetic, and antiinflammatory activities as well as α1A adrenergic receptor antagonists.

InChI:InChI=1/C11H12FN/c12-11-3-1-9(2-4-11)10-5-7-13-8-6-10/h1-5,13H,6-8H2/p+1

Upstream product

• 163631-02-5 1-benzyl-4-(4-fluorophenyl)-4-hydroxypiperidine 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 553631-05-3 tert-butyl 4-hydroxy-4-(4-fluorophenyl)-1-piperidinecarboxylate 

Downstream Products

• 1978-59-2 4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine 
• 478179-20-3 4-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2,6-bis-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile 
• 478179-29-2 4-cyclopropylamino-6-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-2-(2-hydroxy-ethylamino)-pyrimidine-5-carbonitrile 
• 478179-82-7 2-amino-4-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-6-methylsulfanyl-pyrimidine-5-carbonitrile 
• 163630-89-5 4-(4-fluorophenyl)-1,2,3,6-tetrahydro-1-(phenylmethyl)pyridine 
• 37656-48-7 4-(4-fluorophenyl)piperidine 
• 35268-50-9 4'-{2-[4-(p-fluorophenyl)-3,6-dihydro-1(2H)-pyridyl]ethoxy}acetanilide 

Relevant articles and documents

Synthesis and dopaminergic activity of some 3-(1,2,3,6-tetrahydro-1- pyridylalkyl)indoles. A novel conformational model to explain structure- activity relationships

The synthesis and dopaminergic properties of a novel type of dopamine agonist is described. The number and kind of essential structural elements differ significantly from that of the rigid apomorphine-type dopamine agonists. Using standard molecular modeling techniques, a conformational model is developed proposing a U-shaped conformation which might be energetically preferred through aromatic π-π-interactions between both of the electron rich aromatic structural elements of this class of compounds. Superimposition of conformations of the lead compound 28 with apomorphine yields a novel model explaining the atypical structure-activity relationships found in this class of indolealkylamines.