553631-05-3

Basic information

• Product Name: 1-N-BOC-4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDINE
• Synonyms: 1-N-BOC-4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDINE;tert-Butyl 4-(4-fluorophenyl)-4-hydroxypiperidine-1-carboxylate;1-BOC-4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDINE
• CAS NO: 553631-05-3
• Molecular Formula: C₁₆H₂₂FNO₃
• Molecular Weight: 295.352
• Mol File: 553631-05-3.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-N-BOC-4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-N-BOC-4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDINE(553631-05-3)
• EPA Substance Registry System: 1-N-BOC-4-(4-FLUOROPHENYL)-4-HYDROXYPIPERIDINE(553631-05-3)

Safety Data

• Hazardous Substances Data: 553631-05-3(Hazardous Substances Data)

Usage

General Description

1-N-BOC-4-(4-Fluorophenyl)-4-Hydroxypiperidine is a chemical compound that belongs to the piperidine class of organic compounds. It is a derivative of piperidine and has a Boc-(t-butoxycarbonyl) protecting group attached to the nitrogen atom. The compound also contains a 4-fluorophenyl and a 4-hydroxy group attached to the piperidine ring. It is often used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals due to its versatile reactivity and biological properties. The compound has potential applications in the pharmaceutical industry as a building block for the synthesis of drugs targeting neurological disorders, inflammation, and cancer.

Upstream product

• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 352-13-6 4-flourophenylmagnesium bromide 
• 225916-39-2 2-(4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane 
• 1765-93-1 4-fluoroboronic acid 
• 109384-19-2 t-butyl 4-hydroxy piperidine-1-carboxylate 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 1004852-93-0 4-fluoro-4-(4-fluoro-phenyl)-piperidine 
• 1004619-24-2 tert-butyl 4-fluoro-4-(4-fluorophenyl)piperidine-1-carboxylate 
• 39795-58-9 4-(4-fluorophenyl)pyridine 
• 1191240-31-9 4-(4-fluorophenyl)-4-(2-pyrrolidin-1-yl-ethoxy)-piperidine-1-carboxylic acid tert-butyl ester 
• 143682-41-1 3-{4-[4-(4-fluorophenyl)-1-(1,2,3,6-tetrahydro)pyridinyl]-1-butyl}-1H-indole 
• 1027077-17-3 1-[4-(4-Fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-4-(1H-indol-3-yl)-butan-1-one 

Relevant articles and documents

Bulky N-Heterocyclic-Carbene-Coordinated Palladium Catalysts for 1,2-Addition of Arylboron Compounds to Carbonyl Compounds

The synthesis of primary, secondary, and tertiary alcohols by the 1,2-addition of arylboronic acids or boronates to carbonyl compounds, including unactivated ketones, using novel bulky yet flexible N-heterocyclic carbene (NHC)-coordinated 2,6-di(pentan-3-yl)aniline (IPent)-based cyclometallated palladium complexes (CYPs) as catalysts is reported. The PhS-IPent-CYP-catalyzed reactions are efficient at low catalyst loadings (0.02–0.3 mol% Pd), and the exceptional catalytic activity for 1,2-addition is attributed to the steric bulk of the NHC ligand. These reactions can yield a wide range of functionalized benzylic alcohols that are difficult to synthesize by classical protocols using highly active organomagnesium or lithium reagents.

Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.

Ni-catalysed, domino synthesis of tertiary alcohols from secondary alcohols

The use of in situ generated (NHC)-Ni catalytic species (NHC = N-heterocyclic carbene) allows for the synthesis, in short reaction times, of a variety of tertiary alcohols from secondary alcohols through a domino oxidation-addition protocol.