1027187-26-3

Upstream product

• 330173-08-5 N-benzyl-2-(4-methylphenylsulfonyl)acetamide 
• 100-46-9 benzylamine 
• 2564-06-9 N-benzyl-2-chloroacetamide 
• 537048-28-5 N-benzyl-3-(4-chlorophenyl)-5-(4-methylphenylsulfonyl)piperidine-2,6-dione 

Downstream Products

• 537048-29-6 N-benzyl-3-[(4-methylphenyl)sulfonyl]-5-(4-chlorophenyl)-3,4-dihydro-2(1H)-pyridinone 
• 537048-31-0 1-benzyl-5-(4-chloro-phenyl)-3,4-dihydro-1H-pyridin-2-one 
• 41216-03-9 (RS)-5-(4-chlorophenyl)-2-piperidone 

Relevant academic research and scientific papers

Regioselective reduction of N-alkyl-3-sulfonylglutarimide. Formal synthesis of 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine and homobaclofen

Reduction of N-alkyl-3-sulfonylglutarimides with (1) sodium hydride and then with lithium aluminum hydride, or (2) sodium borohydride yielded two different types of regioselectively reduced hydroxypiperidinones which were further dehydrated to two pyridin-2-ones in the presence of boron trifluoride etherate. Cycloaddition and regioselective reduction were combined to synthesize 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine and homobaclofen.