41216-03-9

Upstream product

• 229182-25-6 (RS)-4--3-(4-chlorophenyl)butanenitrile 
• 229182-23-4 methyl (RS)-4--3-(4-chlorophenyl)butanoate 
• 229182-24-5 (RS)-4--3-(4-chlorophenyl)butanol 
• 1134-47-0 4-amino-3-(4-chlorophenyl)butanoic acid 
• 1027187-26-3 1-benzyl-5-(4-chloro-phenyl)-6-hydroxy-3-(toluene-4-sulfonyl)-piperidin-2-one 
• 537048-28-5 N-benzyl-3-(4-chlorophenyl)-5-(4-methylphenylsulfonyl)piperidine-2,6-dione 
• 537048-29-6 N-benzyl-3-[(4-methylphenyl)sulfonyl]-5-(4-chlorophenyl)-3,4-dihydro-2(1H)-pyridinone 
• 537048-31-0 1-benzyl-5-(4-chloro-phenyl)-3,4-dihydro-1H-pyridin-2-one 

Downstream Products

• 87923-04-4 Acetic acid (2S,7R,9aR)-2-tert-butyl-7-(4-chloro-phenyl)-octahydro-quinolizin-2-yl ester 
• 87937-30-2 (2S,7R,9aR)-2-tert-Butyl-7-(4-chloro-phenyl)-octahydro-quinolizin-2-ol 
• 75384-98-4 (1S,7S,9aS)-7-(4-Chloro-phenyl)-2-oxo-octahydro-quinolizine-1-carboxylic acid methyl ester 
• 75385-06-7 7-(4-Chloro-phenyl)-2-oxo-3,4,6,7,8,9-hexahydro-2H-quinolizine-1-carboxylic acid methyl ester 
• 75384-89-3 (7S,9aS)-7-(4-Chloro-phenyl)-octahydro-quinolizin-2-one 
• 87922-80-3 3-(4-Chloro-phenyl)-6-ethoxy-2,3,4,5-tetrahydro-pyridine 

Relevant academic research and scientific papers

Regioselective reduction of N-alkyl-3-sulfonylglutarimide. Formal synthesis of 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine and homobaclofen

Reduction of N-alkyl-3-sulfonylglutarimides with (1) sodium hydride and then with lithium aluminum hydride, or (2) sodium borohydride yielded two different types of regioselectively reduced hydroxypiperidinones which were further dehydrated to two pyridin-2-ones in the presence of boron trifluoride etherate. Cycloaddition and regioselective reduction were combined to synthesize 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizine and homobaclofen.

Synthesis and pharmacology of the baclofen homologues 5-amino-4-(4- chlorophenyl)pentanoic acid and the R- and S-enantiomers of 5-amino-3-(4- chlorophenyl)pentanoic acid

(RS)-5-Amino-4-(4-chlorophenyl)pentanoic acid (10) and the R-form (11) and S-form (12) of (RS)-5-amino-3-(4-chlorophenyl)pentanoic acid, which are homologues of the 4-aminobutanoic acid(B) (GABA(B)) receptor agonist (RS)-4- amino-3-(4-chlorophenyl)butanoi