1027190-57-3Relevant academic research and scientific papers
Synthesis of the 'southern' tripeptide of Cyclomarins A and C having novel anti-tuberculocidal mode of action
Sathish, Kurapati,Reddy, Gangireddy Pavan Kumar,Mainkar, Prathama S.,Chandrasekhar, Srivari
, p. 1568 - 1573 (2011/12/14)
The synthesis of the 'southern' tripeptide of Cyclomarins A and C has been described which includes two unusual amino acids. The unusual amino acids have been synthesized and coupled with l-alanine to obtain the tripeptide.
Syntheses of four unusual amino acids, constituents of cyclomarin A
Sugiyama, Hideyuki,Shioiri, Takayuki,Yokokawa, Fumiaki
, p. 3489 - 3492 (2007/10/03)
The stereoselective syntheses of four unusual amino acids, constituents of cyclomarin A, are described. The protected N-methylhydroxyleucine 2 was synthesized using Evans' asymmetric azide-transfer reaction. The unusual amino acid 3 was prepared via diastereoselective methylation of the L-aspartic acid derived lactone 13. The stereoselective formation of threo-β-methoxyphenylalanine 4 was performed via aldol reaction using Scho?llkopf's chiral glycine enolate. The synthesis of N-reverse prenylated tryptophane 5 was achieved by the AQN ligand-promoted Sharpless regioreversed asymmetric aminohydroxylation protocol.
