1027367-16-3

Upstream product

• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 204577-67-3 (1R)-2-endo-acetyl-2-exo-(trimethylsilyloxy)-1,7,7-trimethylbicyclo[2.2.1]heptane 

Downstream Products

• 363152-47-0 (S)-3-(4-Chloro-phenyl)-1-((1R,2R,4R)-2-hydroxy-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl)-4-nitro-butan-1-one 
• 464-49-3 (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one 
• 123632-31-5 (S)-(+)-4-(4-chlorophenyl)pyrrolidin-2-one 
• 750649-51-5 (S)-(+)-3-(4-chloro-phenyl)-4-nitro-butyric acid 
• 363152-43-6 (S)-methyl 3-(4-chlorophenyl)-4-nitrobutanoate 

Relevant academic research and scientific papers

Diastereoselective Michael reactions of (1R)-(+)-camphor methyl ketone enolates with nitro olefins

The reaction of the sodium enolate of the methyl ketone 2 with a range of nitro olefins proceeds readily to give the corresponding Michael adducts in good yields and diastereoselectivities. Subsequent oxidative cleavage of the acyloin moiety provides γ-nitroalkanoic acids along with (1R)-(+)-camphor, the chiral auxiliary of the process, which can be recovered and reused.