750649-51-5

Basic information

• Product Name: (S)-(+)-3-(4-chloro-phenyl)-4-nitro-butyric acid
• Synonyms: (S)-(+)-3-(4-chloro-phenyl)-4-nitro-butyric acid
• CAS NO: 750649-51-5
• Molecular Weight: 243.647
• Mol File: 750649-51-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (S)-(+)-3-(4-chloro-phenyl)-4-nitro-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(+)-3-(4-chloro-phenyl)-4-nitro-butyric acid(750649-51-5)
• EPA Substance Registry System: (S)-(+)-3-(4-chloro-phenyl)-4-nitro-butyric acid(750649-51-5)

Safety Data

• Hazardous Substances Data: 750649-51-5(Hazardous Substances Data)

Upstream product

• 101466-69-7 methyl (+/-)-3-(4-chlorophenyl)-4-nitrobutanoate 
• 1001058-66-7 (S)-3-(4-chlorophenyl)-4-nitrobutyraldehyde 
• 1075-77-0 (E)-4-chlorocinnamic aldehyde 
• 1205553-67-8 (S)-5-(2-(4-chlorophenyl)-3-nitropropyl)-3-methyl-4-nitroisoxazole 
• 1027367-16-3 (S)-3-(4-Chloro-phenyl)-4-nitro-1-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-butan-1-one 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 159112-23-9 3-(4-chlorophenyl)-4-nitrobutanoic acid 
• 1615-02-7 3-(4-chlorophenyl)prop-2-enoic acid 
• 20754-21-6 methyl 3-(4-chlorophenyl)propenoate 
• 750649-48-0 (3S,3'S)-4,4-dimethyl-2-oxo-1-phenylpyrrolidin-3-yl 4-nitro-3-(4-chlorophenyl)butanoate 
• 363152-47-0 (S)-3-(4-Chloro-phenyl)-1-((1R,2R,4R)-2-hydroxy-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl)-4-nitro-butan-1-one 

Downstream Products

• 363152-43-6 (S)-methyl 3-(4-chlorophenyl)-4-nitrobutanoate 
• 123632-31-5 (S)-(+)-4-(4-chlorophenyl)pyrrolidin-2-one 
• 63701-56-4 (+)-Baclofen hydrochloride 

Relevant articles and documents

Telescoped Continuous Flow Synthesis of Optically Active γ-Nitrobutyric Acids as Key Intermediates of Baclofen, Phenibut, and Fluorophenibut

The two-step flow asymmetric synthesis of chiral γ-nitrobutyric acids as key intermediates of the GABA analogues baclofen, phenibut, and fluorophenibut is reported on a multigram scale. The telescoped process comprises an enantioselective Michael-type add

Catalytic asymmetric conjugate addition of nitroalkanes to 4-nitro5-styrylisoxazoles

(Chemical equation presented) Nitro versus nitro: 4-Nitro-5- styrylisoxazoles were used as masked α,β-unsaturated carboxylic acids in the titled catalytic asymmetric transformation. The 4-nitroisoxazole core acts as an activator of the conjugated alkene and a latent carboxylate functionality. The reaction proceeded with 5 mol% of a readily prepared phasetransfer catalyst at room temperature with remarkable diastereo- and enantioselectivity (see scheme).

Highly enantioselective organocatalytic conjugate addition of nitromethane to α,β-unsaturated aldehydes: Three-step synthesis of optically active baclofen

An efficient, organocatalytic, highly enantioselective, conjugate addition reaction of nitromethane with α,β-unsaturated aldehydes has been developed. The process serves as the key step for a practical 3-step synthesis of chiral baclofen, an antispastic drug.