363152-43-6

Basic information

• Product Name: (S)-methyl 3-(4-chlorophenyl)-4-nitrobutanoate
• Synonyms: (S)-methyl 3-(4-chlorophenyl)-4-nitrobutanoate
• CAS NO: 363152-43-6
• Molecular Weight: 257.674
• Mol File: 363152-43-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (S)-methyl 3-(4-chlorophenyl)-4-nitrobutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-methyl 3-(4-chlorophenyl)-4-nitrobutanoate(363152-43-6)
• EPA Substance Registry System: (S)-methyl 3-(4-chlorophenyl)-4-nitrobutanoate(363152-43-6)

Safety Data

• Hazardous Substances Data: 363152-43-6(Hazardous Substances Data)

Upstream product

• 1001058-66-7 (S)-3-(4-chlorophenyl)-4-nitrobutyraldehyde 
• 67-56-1 methanol 
• 750649-51-5 (S)-(+)-3-(4-chloro-phenyl)-4-nitro-butyric acid 
• 1075-77-0 (E)-4-chlorocinnamic aldehyde 
• 75-52-5 nitromethane 
• 1075-77-0 4-chlorocinnamaldehyde 
• 1385860-98-9 3,5-dimethyl-1-[3-(4-chlorophenyl)propanonyl]pyrazole 
• 563-70-2 bromonitromethane 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 1027367-16-3 (S)-3-(4-Chloro-phenyl)-4-nitro-1-((1R,2R,4R)-1,7,7-trimethyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-2-yl)-butan-1-one 
• 363152-47-0 (S)-3-(4-Chloro-phenyl)-1-((1R,2R,4R)-2-hydroxy-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl)-4-nitro-butan-1-one 
• 706-07-0 1-chloro-4-(2-nitrovinyl)benzene 
• 186581-53-3 diazomethane 

Downstream Products

• 948017-83-2 C₁₁H₁₄ClNO₂ 
• 123632-31-5 (S)-(+)-4-(4-chlorophenyl)pyrrolidin-2-one 

Relevant articles and documents

Organocatalytic asymmetric nitrocyclopropanation of α,β-unsaturated aldehydes

A novel organocatalytic highly enantioselective nitrocyclopropanation reaction of α,β-unsaturated aldehydes is presented. The 1-nitro-2-formylcyclopropane derivatives synthesized from this catalytic transformation were converted to the corresponding β-nitromethyl-acid esters, which are excellent precursors of GABA analogues such as Baclofen, by subsequent organocatalytic chemoselective ring-opening.

Asymmetric synthesis of functionalized pyrrolizidines by an organocatalytic and pot-economy strategy

An efficient method has been developed for the enantioselective synthesis of tetrahydro-1H-pyrrolizin-3(2H)-ones starting from α,β-unsaturated aldehydes via a sequence of asymmetric Michael-oxidative esterification-Michal-reduction-reductive amination-lactamization reactions with high enantioselectivities (93-97% ee). The six-step reaction sequence can be conducted with the pot-economy synthetic strategy with only a one-step purification. The structure and absolute stereochemistry of the intermediates and products were confirmed by X-ray analyses of appropriate products.

Asymmetric synthesis of γ-nitroesters by an organocatalytic one-pot strategy

An enantioselective synthesis of γ-nitroesters by a one-pot asymmetric Michael addition/oxidative esterification of α,β- unsaturated aldehydes is presented. The procedure is based on merging the enantioselective organocatalytic nitroalkane addition with an N-bromosuccinimide-based oxidation. The γ-nitroesters are obtained in good yields and enantioselectivities, and the method provides an attractive entry to optically active γ-aminoesters, 2-piperidones, and 2-pyrrolidones.