1028072-66-3Relevant academic research and scientific papers
NOVEL DIHYDROXYPYRROLIDINE DERIVATIVES AS ANTI-CANCER AGENTS
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, (2009/10/22)
The present invention provides new dihydroxypyrrolidine derivatives for use as medicaments. The compounds are useful in the treatment in cancer, in particular non-solid neoplasms.
An RCM strategy to stereodiverse δ-sultam scaffolds
Jimenez-Hopkins, Maria,Hanson, Paul R.
supporting information; experimental part, p. 2223 - 2226 (2009/05/11)
(Chemicall Equation Presented) An asymmetric approach for the synthesis of substituted δ-sultams with multiple synthetic handles is described. This study demonstrates the facile construction of a stereochemically diverse array of substituted δ-sultams, more specifically substituted 3,4,5,6-dihydro 1,2-thiazine 1,1-dioxides. A pivotal Mitsunobu alkylation/RCM sequence is used to assemble key allyl sultam building blocks possessing a C3 stereogenic handle. All subsequent reactions are achieved with high levels of diastereoselectivity to afford enantiopure δ-sultams in good yields.
Synthesis of Vinyl Sulfonamides Using the Horner Reaction
Reuter, Deborah C.,McIntosh, Joel E.,Guinn, Ashley C.,Madera, Ann Marie
, p. 2321 - 2324 (2007/10/03)
A series of vinyl sulfonamides was synthesized using the Horner reaction of aldehydes and diphenylphosphorylmethane-sulfonamide. The sulfonamide reagent was easily prepared and can be stored indefinitely. The trans orientation about the double bond of the vinyl sulfonamides was the only isomer observed.
