10286-78-9

Upstream product

• 98-88-4 benzoyl chloride 
• 95-74-9 3-chloro-p-toluidine 
• 28479-22-3 2-chloro-4-isocyanato-1-methylbenzene 
• 98-80-6 phenylboronic acid 
• 95-73-8 2,4-dichlorotoluene 
• 55-21-0 benzamide 
• 89794-02-5 4-bromo-2-chlorotoluene 
• 83846-48-4 3-chloro-4-methyliodobenzene 
• 95-49-8 2-methylchlorobenzene 
• 121-86-8 2-chloro-4-nitrotoluene 
• 65440-81-5 O-(4-methylphenyl)hydroxylamine 
• 74993-55-8 N-p-Tolyloxy-benzamide 

Downstream Products

• 1323369-24-9 N-(3-chloro-4-(7-chloro-6-methyl-2-phenyl-4H-benzo[d][1,3]oxazin-4-yl)phenyl)benzamide 

Relevant academic research and scientific papers

Modular Continuous Flow Synthesis of Imatinib and Analogues

A modular continuous flow synthesis of imatinib and analogues is reported. Structurally diverse imatinib analogues are rapidly generated using three readily available building blocks via a flow hydration/chemoselective C-N coupling sequence. The newly developed continuous flow hydration and amidation modules each exhibit a broad scope with good to excellent yields. Overall, the method described does not require solvent switches, in-line purifications, or packed-bed apparatuses due to the judicious manipulation of flow setups and solvent mixtures.

Copper-catalyzed dehydrogenative cross-coupling reactions of N-para-tolylamides through successive C-H activation: Synthesis of 4H-3,1-benzoxazines

A novel annulation reaction of readily available tolylamides was catalyzed by Cu(OTf)2 in the presence of Selectfluor and water through successive intermolecular C-H activated dehydrogenative cross-coupling reactions of benzylic methyl C(sp3)-H and aromatic C(sp2)-H bonds, and subsequent intramolecular C-O bond formation (see scheme). Copyright

Palladium-catalyzed addition of arylboronic acids to isocyanates

The addition of arylboronic acids to isocyanates catalyzed by palladium acetate in the presence of triphenylphosphine as the ligand is described.

AlCl3-mediated migration of benzamido group of N-phenoxybenzamide derivatives to the phenyl group

AlCl3-mediated decomposition of N-phenoxybenzamide derivatives in dichloromethane mainly leads to regioselective intramolecular migration of benzamido group from the oxygen to the ortho position of the phenyl group via electron-deficient nitrogen intermediates.