10286-88-1

Upstream product

• 82344-31-8 N-(o-chlorophenyl)benzohydroxamic acid 
• 157491-02-6 (E)-2,6-dichlorobenzophenone oxime 
• 90-99-3 diphenylchloromethane 
• 2904-62-3 2,6-dichlorobenzonitrile N-oxide 
• 13391-37-2 1-(chlorophenylmethyl)-3-methoxybenzene 
• 341-02-6 trityl tetrafluoroborate 
• 10468-16-3 2-chloro-N-hydroxybenzenamine 
• 93-58-3 benzoic acid methyl ester 
• 608-31-1 2,6-Dichloroaniline 
• 98-88-4 benzoyl chloride 
• 76-83-5 trityl chloride 
• 93-89-0 benzoic acid ethyl ester 

Downstream Products

• 608-31-1 2,6-Dichloroaniline 
• 137090-09-6 N-(2,6-Dichloro-phenyl)-N-methyl-benzamide 

Relevant academic research and scientific papers

Microwave-Assisted Organic Synthesis, structure–activity relationship, kinetics and molecular docking studies of non-cytotoxic benzamide derivatives as selective butyrylcholinesterase inhibitors

A series of benzamide derivatives 1–12 with various functional groups (–H, –Br, –F, –OCH3, –OC2H5, and –NO2) was synthesized using an economic, and facile Microwave-Assisted Organic Synthesis, and evaluated for

On DABAL-Me3 promoted formation of amides

The range and utility of DABAL-Me3 couplings of methyl esters and free carboxylic acids with primary and secondary amines under a variety of conditions (reflux, sealed tube, microwave) has been compared for a significant range of coupling partners of relevance to the preparation of amides of interest in pharmaceutical chemistry. Commercial microwave reactors promote the fastest couplings and allow the use of significantly sterically hindered amines (primary and secondary) and carboxylic acids derivatives. The influence of microwave energy on the reaction system was shown to be typically related to thermal effects (over-pressuring and superheating).

Reactions between nitrile oxides and carbenium ions: Synthesis of benzoxazines, oximes, and amides through intramolecular ortho or ipso attack

Reactions between nitrile oxides and benzylic carbocations are described. Different results were obtained when the carbocations were generated from the corresponding chlorides with different Lewis acids, with addition products such as benzoxazines, oximes, and amides being produced. Primary, secondary, and tertiary carbocations showed different reactivities. The product ratios strongly depended on the substituents on the aromatic ring of the benzylic carbocations. Evidence for the proposed mechanism is reported. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.

Nitrile oxide-BF3 complex as electrophilic moiety towards aromatic systems: Stereospecific synthesis of oximes

Aromatic oximes are obtained stereospecifically by action of nitrile oxide-BF3 complexes on aromatic compounds.

Novel Reactions: Part I - Facile Synthesis of Substituted ortho-Chloranilines from Nitrobenzene Derivatives

N-Substituted benzo and acetohydroxamic acids (5), prepared from N-arylhydroxylamines and benzoyl or acetyl chloride, react readily with thionyl chloride at low temperature to give ortho-chloroanilide derivatives (6) in good yield.The latter (6) on hydrolysis give ortho-chloroanilines (10).Since the N-arylhydroxylamines are obtained from nitroarenes by partial reduction, the overall reaction amounts to the preparation of 10 from nitroarenes.

NOVEL ORTHOHALOGENATION REACTION. SYNTHESIS OF ORTHOCHLOROARYLAMINES FROM NITROARENES.

Thionyl chloride reacts with N-phenylbenzo and N-phenylaceto-hydroxamic acids at low temperatures to give ortho-chloroanilide derivatives in good yield.