102872-00-4Relevant articles and documents
Preparation method of 5-aminolevulinic acid hydrochloride
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Paragraph 0028; 0035; 0038; 0040-0042; 0045, (2018/01/14)
The invention relates to a preparation method of 5-aminolevulinic acid hydrochloride, belonging to the technical field of drug intermediate synthesis. In order to solve the problems of long route and great pollution at present, the invention provides the preparation method of the 5-aminolevulinic acid hydrochloride. The preparation method is characterized in that the method comprise the following steps of under the existence of organic alkali and DMAP, enabling benzoyl glycine to react with butanedioic anhydride by using Dakin-West to obtain benzoyl aminolevulinic acid; under the existence of hydrochloric acid, enabling the benzoyl aminolevulinic acid to be subjected to hydrolysis reaction to obtain the 5-aminolevulinic acid hydrochloride. The synthetic method has the advantages that the reaction route is short, the raw materials are convenient to obtain, the cost is low, the reaction operation is simple and convenient and the pollution is less, and the method has the effects of high product yield and high purity.
