10289-08-4

Upstream product

• 75-44-5 phosgene 
• 29456-09-5 L-glutamic acid γ-benzyl ester 
• 62457-19-6 N-benzyloxycarbonyl-glutamic acid 5-benzyl ester 1-tert-butyl ester 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 63228-51-3 L-aspartic acid beta-benzyl ester 
• 1676-73-9 glutamic acid γ-benzyl ester 
• 13574-13-5 Boc-Glu(OBzl)-OH 
• 3283-43-0 γ-benzyl glutamic acid 
• 1676-73-9 L-glutamic acid γ-benzyl ester 
• 100-51-6 benzyl alcohol 
• 617-65-2 Glutamic acid 

Relevant academic research and scientific papers

Novel 3D Neuron Regeneration Scaffolds Based on Synthetic Polypeptide Containing Neuron Cue

Neural tissue engineering has become a potential technology to restore the functionality of damaged neural tissue with the hope to cure the patients with neural disorder and to improve their quality of life. This paper reports the design and synthesis of polypeptides containing neuron stimulate, glutamic acid, for the fabrication of biomimetic 3D scaffold in neural tissue engineering application. The polypeptides are synthesized by efficient chemical reactions. Monomer γ-benzyl glutamate-N-carboxyanhydride undergoes ring-opening polymerization to form poly(γ-benzyl-l-glutamate), then hydrolyzes into poly(γ-benzyl-l-glutamate)-r-poly(glutamic acid) random copolymer. The glutamic acid amount is controlled by hydrolysis time. The obtained polymer molecular weight is in the range of 200 kDa for good quality of fibers. The fibrous 3D scaffolds of polypeptides are fabricated using electrospinning techniques. The scaffolds are biodegradable and biocompatible. The biocompatibility and length of neurite growth are improved with increasing amount of glutamic acid in scaffold. The 3D scaffold fabricated from aligned fibers can guide anisotropic growth of neurite along the fiber and into 3D domain. Furthermore, the length of neurite outgrowth is longer for scaffold made from aligned fibers as compared with that of isotropic fibers. This new polypeptide has potential for the application in the tissue engineering for neural regeneration.

Synthesis of alkyl-modified poly(sodium glutamate)s for preparation of polymer-protein nanoparticles in combination with N,N,N-trimethyl chitosan

The negatively charged, water-soluble, hydrophobically modified poly(sodium glutamate)s containing different amounts of alkyl grafts were synthesized. First, poly(γ-benzyl-L-glutamate) was prepared by ring-opening polymerization of the corresponding N-carboxyanhydride, which was in the next step aminolysed with octylamine. After removal of the remaining benzyl protective groups, the alkyl-modified poly(sodium glutamate)s [P(Glu-oa)] were obtained and, together with the oppositely charged N,N,N-trimethyl chitosan (TMC), used for the preparation of nanoparticles (NPs) of a recombinant granulocyte colony-stimulating factor (GCSF) protein by polyelectrolyte complexation method. It is observed that, beside electrostatic interaction, the hydrophobic grafts on poly(sodium glutamate)s significantly contribute to association efficiency (AE) with GCSF protein. The addition of TMC solution to the dispersion of GCSF/P(Glu-oa) complexes results in formation of much more defined NPs with high AE and final protein loading.

Efficient preparation of proline N-carboxyanhydride using polymer-supported bases

A procedure for the preparation of proline N-carboxyanhydride in high yield and purity is described using polymer-supported tertiary amines. The polymer-supported amine can be recycled with a basic wash and filtration of the resin. The procedure facilitates the access to the efficient preparation of the polyproline polymer with potential therapeutic interest.

Redox-Responsive Biomimetic Polymeric Micelle for Simultaneous Anticancer Drug Delivery and Aggregation-Induced Emission Active Imaging

Intelligent polymeric micelles have been developed as potential nanoplatforms for efficient drug delivery and diagnosis. Herein, we successfully prepared redox-sensitive polymeric micelles combined aggregation-induced emission (AIE) imaging as an outstanding anticancer drug carrier system for simultaneous chemotherapy and bioimaging. The amphiphilic copolymer TPE-SS-PLAsp-b-PMPC could self-assemble into spherical micelles, and these biomimetic micelles exhibited great biocompatibility and remarkable ability in antiprotein adsorption, showing great potential for biomedical application. Anticancer drug doxorubicin (DOX) could be encapsulated during the self-assembly process, and these drug-loaded micelles showed intelligent drug release and improved antitumor efficacy due to the quick disassembly in response to high levels of glutathione (GSH) in the environment. Moreover, the intracellular DOX release could be traced through the fluorescent imaging of these AIE micelles. As expected, the in vivo antitumor study exhibited that these DOX-carried micelles showed better antitumor efficacy and less adverse effects than that of free DOX. These results strongly indicated that this smart biomimetic micelle system would be a prominent candidate for chemotherapy and bioimaging.

Synthesis and characterization of ultrathin metal coordination Prussian blue nanoribbons

Ultrathin metal coordination Prussian blue (PB) nanoribbons with tunable width have been successfully synthesized. The morphology and microstructure of PB nanoribbons are characterized using UV-vis, FT-IR, AFM, TEM and XRD. PB nanoribbons synthesized possess an ultrathin thickness of approximately 1 nm and narrow width. The width of PB ribbons can be tuned by varying the chain length of polymeric precursors. The PB hybrid nanoribbons synthesized exhibit enhanced thermal stability and electrochemical activity. The merit of narrow and tunable width as well as ultrathin thickness of PB hybrid nanoribbons along with enhanced thermal stability and electrochemical activity makes them potentially useful in nano-devices, biosensors and so on.

Block copolypeptides. 1. Synthesis and solid state conformational studies.

Triblock copolypeptides of gamma-benzyl L-glutamate (G) and L-leucine or L-valine of high molecular weight have been prepared. The solubilites and solution conformation were determined and compared with random copolymers of similar composition as well as the appropriate homopolypeptides. Characterization of the secondary structure in the solid state was undertaken as part of an investigation into the solid state properties of this new class of materials. Infrared and solid state measurements indicate that the G and L-leucine blocks assume an alpha-helical conformation and L-valine blocks a beta-sheet structure. Polarized infrared measurements showed the chain axis in oriented films to be parallel to the orientation direction. Further solid state characterization of the tertiary structure and mechanical properties of the block copolypeptides will be reported in succeeding papers.

Biodegradable supramolecular micellesviahost-guest interaction of cyclodextrin-terminated polypeptides and adamantane-terminated polycaprolactones

Biodegradable supramolecular micelles were prepared exploiting the host-guest interaction of cyclodextrin and adamantane. Cyclodextrin-initiated polypeptides acted as the hydrophilic corona, whereas adamantane-terminated polycaprolactones served as the hydrophobic core.

Preparation method and application of folic acid-targeted dual-drug-loaded nanoparticles

The invention relates to a preparation method and application of folic acid-targeted dual-drug-loaded nanoparticles, and can effectively solve problems that anti-tumor drugs are low in water solubility, serious in toxic and side effects, lack of targeting, etc. A technical solution is to prepare dendrimers PLD and polyglutamic acid (PGA), and paclitaxel, gemcitabine and folic acid are loaded on the PGA to obtain PGA-PTX, PGA-GEM and PGA-FA. The four materials in an aqueous solution are attracted to each other by positive and negative charges, and self-assembled to form the nanoparticles, and particle diameters of the nanoparticles are about (190 plus or minus 15) nm. The nanoparticles enter tumor cells and release the paclitaxel and the gemcitabine through combination of the folic acid andfolic acid receptors on surfaces of the tumor cells, thereby inhibiting proliferation of the tumor cells and promoting apoptosis. The drug-loaded nanoparticles can effectively inhibit growth of tumorcells 4T1 and have a better inhibitory effect on tumor models of the 4T1 cells in vivo.

Nano-cluster for treating cancer and preparation method of nano-cluster

The invention relates to the technical field of polymer drug carriers, and in particular relates to a nano-cluster for treating cancer and a preparation method of the nano-cluster. The preparation method includes the following steps: A) performing a reaction on a first mixed liquid and a second mixed liquid to obtain a product solution, wherein the first mixed liquid includes polyamino acid nanoparticles loaded with cisplatin, sodium phosphate, sodium chloride, N-(2-hydroxyethyl)piperazin-N'-2-ethanesulfonic acid and water, and the second mixed solution includes arsenic trioxide, calcium chloride and water; and B) performing dialysis on the product solution, and performing lyophilization to obtain the nano-cluster for treating the cancer. The nano-cluster for treating the cancer prepared by the method can be enriched in tumor tissue parts through the enhanced permeability and retention (EPR) effect, and release the cisplatin and the arsenic trioxide with anti-tumor properties under thepH condition in tumor cells to synergistically inhibit tumor growth, reduce the toxic and side effects on non-lesional sites, and improve the treatment coefficient of tumor sites.

Polyionic type micelle shielding system with electric charge turnover function and preparation method thereof

The invention provides a polyionic type micelle shielding system with reversible charges. The polyionic type micelle shielding system is formed by a compound shown as formula (III) and cis-diamminedichloroplatinum through coordination. According to the polyionic type micelle shielding system with the reversible charges, cis-diamminedichloroplatinum is supported under a coordination action, a support material is good in biocompatibility and solubility, the nano-support is enriched at a tumor tissue part through an EPR (enhanced permeability and retention effect), a shell with a shielding capability is removed under the condition of pH at the tumor tissue part, a positively charged cis-diamminedichloroplatinum supported core is exposed, endocytosis is facilitated by the positively charged core, and after the cis-diamminedichloroplatinum supported core enters a cell, the drug cis-diamminedichloroplatinum with anti-tumor performance is released by the cis-diamminedichloroplatinum supportedcore.