1028981-87-4Relevant academic research and scientific papers
Synthesis of selenated tetracyclic indoloazulenesviaiodine and diorganyl diselenides
Win, Khin Myat Noe,Sonawane, Amol D.,Koketsu, Mamoru
, p. 3199 - 3206 (2021)
Herein, we report an efficient protocol for the synthesis of selenated tetracyclic indoloazulenes. The reaction of diorganyl diselenides with molecular iodine in dichloromethane leads to thein situformation of organo selenenyl iodide. The synthesis of selenylated tetracyclic indoloazulenes through intramolecular cascade cyclization has been achievedviaorgano selenenyl iodide and bisindole at room temperature under metal-free conditions in good yields. All compounds were fully characterized by the FT-IR, HRMS, and1H,13C and77Se NMR spectral data.
Molecular iodine-mediated cascade reaction of 2-alkynylbenzaldehyde and indole: An easy access to tetracyclic indoloazulene derivatives
Gawande, Sachin D.,Kavala, Veerababurao,Zanwar, Manoj R.,Kuo, Chun-Wei,Huang, Hsiu-Ni,He, Chiu-Hui,Kuo, Ting-Shen,Yao, Ching-Fa
supporting information, p. 3022 - 3036 (2014/03/21)
The synthesis of iodo-substituted tetracyclic indole fused azulene derivatives was achieved from the reaction of 2-(substituted phenylethynyl)-benzaldehydes and different indoles in the presence of molecular iodine. The reaction involves the formation of a bisindole from the corresponding 2-(substituted phenylethynyl)benzaldehyde and indole followed by iodocyclization in a one-pot cascade process. A wide range of 2-(substituted phenylethynyl)-benzaldehydes and indoles were utilized in this protocol to derive a diverse range of iodo-substituted tetracyclic indole fused azulene derivatives in moderate to good yields. Further functionalizations of the iodo-substituted tetracyclic indole fused azulenes were achieved by various palladium-catalyzed crosscoupling reactions to generate highly substituted tetracyclic indole fused azulene derivatives.
Synthesis of 1-(1H-Indol-3-yl)-l,2-dihydroisoquinolines via AgOTf-catalyzed three-component reactions of 2-alkynylbenzaldehydes, amines, and indoles
Yu, Xingxin,Wu, Jie
scheme or table, p. 238 - 244 (2010/08/22)
Three-component reactions of 2-alkynylbenzaldehydes, amines, and indoles catalyzed by AgOTf under mild conditions afford the 1-(1H-indol-3-yl)-l,2- dihydroisoquinolines in good yields. This silver-catalyzed tandem reaction is found to be workable with var
Sc(OTf)3-catalyzed or t-BuOK promoted tandem reaction of 2-(2-(alkynyl)benzylidene)malonate with indole
Gao, Ke,Wu, Jie
supporting information; experimental part, p. 2251 - 2254 (2009/05/26)
(Chemical Equation Presented) Tandem reaction of 2-(2-(alkynyl)benzylidene) malonate with indole was investigated. (Z)-1-Benzylidene-3-(1H-indol-1-yl)-1H- indene-2,2(3H)-dicarboxylate was generated in the presence of t-BuOK at room temperature; whereas 3-((1H-indol-3-yl)(2-(alkynyl)aryl)methyl)-1H-indole was obtained when Sc(OTf)3 was utilized as catalyst at 50°C.
