1029080-42-9

Basic information

• Product Name: 2,2-dichloro-3-(4-fluorophenyl)cyclobutanone
• Synonyms: 2,2-dichloro-3-(4-fluorophenyl)cyclobutanone
• CAS NO: 1029080-42-9
• Molecular Weight: 233.069
• Mol File: 1029080-42-9.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: 2,2-dichloro-3-(4-fluorophenyl)cyclobutanone(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-dichloro-3-(4-fluorophenyl)cyclobutanone(1029080-42-9)
• EPA Substance Registry System: 2,2-dichloro-3-(4-fluorophenyl)cyclobutanone(1029080-42-9)

Safety Data

• Hazardous Substances Data: 1029080-42-9(Hazardous Substances Data)

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 76-02-8 trifluoroacetyl chloride 
• 405-99-2 para-fluorostyrene 

Downstream Products

• 143589-42-8 3-(4'-fluorophenyl)cyclobutan-1-one 
• 1383658-29-4 3-(4-fluorophenyl)cyclobut-2-en-1-one 
• 1033082-33-5 (-)-(R)-4-(4-fluorophenyl)dihydrofuran-2(3H)-one 

Relevant articles and documents

Synthesis of Silylated Cyclobutanone and Cyclobutene Derivatives Involving 1,4-Addition of Zinc-Based Silicon Nucleophiles

A copper-catalyzed conjugate silylation of various cyclobutenone derivatives with Me2PhSiZnCl ? 2LiCl or (Me2PhSi)2Zn ? xLiCl (x≤4) to generate β-silylated cyclobutanones is reported. Trapping the intermediate enolate with ClP(O)(OPh)2 affords silylated enol phosphates that can be further engaged in Kumada cross-coupling reactions to yield silylated cyclobutene derivatives.

Manganese=Catalyzed Achmatowicz Rearrangement Using Green Oxidant H2O2

Oxidation reactions have been extensively studied in the context of the transformations of biomass=derived furans. However, in contrast to the vast literature on utilizing the stoichiometric oxidants, such as m=CPBA and NBS, catalytic methods for the oxidative furan=recyclizations remain scarcely investigated. Given this, we report a means of manganese=catalyzed oxidations of furan with low loading, achieving the Achmatowicz rearrangement in the presence of hydrogen peroxide as an environmentally benign oxidant under mild conditions with wide functional group compatibility.

Baeyer-Villiger Oxidation of Cyclobutanones with 10-Methylacridinium as an Efficient Organocatalyst

Baeyer-Villiger oxidation of cyclobutanones is achieved in current developed protocol with 10-methylacridinium perchlorate (AcrH +ClO4-) as a novel organocatalyst both with irradiation at room temperature and without irradiation at elevated temperature. Excellent yields of the corresponding lactones are obtained and the possible mechanism has been proposed.