10295-51-9

Basic information

• Product Name: Benzeneacetamide, a-hydroxy-N-(4-methylphenyl)-
• CAS NO: 10295-51-9
• Molecular Formula: C15H15NO2
• Molecular Weight: 241.29
• Mol File: 10295-51-9.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: Benzeneacetamide, a-hydroxy-N-(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneacetamide, a-hydroxy-N-(4-methylphenyl)-(10295-51-9)
• EPA Substance Registry System: Benzeneacetamide, a-hydroxy-N-(4-methylphenyl)-(10295-51-9)

Safety Data

• Hazardous Substances Data: 10295-51-9(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 611-71-2 MANDELIC ACID 
• 25726-04-9 phenylglyoxylyl chloride 
• 98-86-2 acetophenone 
• 611-73-4 Benzoylformic acid 
• 624-31-7 4-tolyl iodide 
• 4410-31-5 (RS)-mandelamide 
• 106-38-7 para-bromotoluene 
• 103-82-2 phenylacetic acid 
• 19711-87-6 2-oxo-2-diphenyl-N-(p-tolyl)acetamide 
• 222851-56-1 N-phenylsulfinylamine 
• 15795-42-3 N-sulfinyl-4-methylaniline 

Downstream Products

• 17539-90-1 N-(p-tolyl)-1-phenyl-2-aminoethanol 
• 13228-36-9 5-methyl-2-phenyl-1H-indole 
• 672959-71-6 2-amino-2-phenyl-N-(4-tolyl)acetamide 
• 10295-50-8 chloro-phenyl-acetic acid p-toluidide 
• 24918-51-2 5-methyl-3-phenylindolin-2-one 

Relevant articles and documents

“On-water” reduction of α-keto amide by Hantzsch ester: A chemoselective catalyst- and additive-free way to α-hydroxy amide

An efficient and practical method for chemoselective “on-water” reduction of α-keto amide by Hantzsch ester without using any catalysts and additives was developed. Control experiments indicated that the intramolecular hydrogen bond of α-keto amide was cr

Zirconium-MOF-catalysed selective synthesis of α-hydroxyamide via the transfer hydrogenation of α-ketoamide

This work reports the synthesis of α-hydroxy amide and its derivatives using zirconium-based metal-organic frameworks (Zr-MOFs). The Zr-MOF was prepared using a ligand containing different functionalities as a linker with different porosities. The catalyst efficiently facilitated the transfer hydrogenation of α-ketoamide to α-hydroxyamide. The reaction involved a green hydrogen source, namely isopropyl alcohol, which also acted as a solvent. The role of the ligand in the catalyst was optimized for the selective conversion of α-ketoamide to α-hydroxyamide. UiO-66 (Zr) crystal was efficiently used for the first time for the hydrogenation of α-ketoamide to α-hydroxyamide. The catalyst was recovered and recycled five times without any loss in activity and selectivity performance. The morphology, activity and stability of the UiO-66 (Zr) catalyst were analyzed using field emission gun scanning electron microscopy (FEG-SEM), X-ray diffraction (XRD), infra-red (IR) spectroscopy and thermogravimetric analysis (TGA). The existence of α-hydroxyamide and its derivatives was confirmed from 1H and 13C-NMR.

Method for preparing alpha-hydroxyamide by reducing alpha-keto amides

The invention relates to a method for preparing alpha-hydroxyamide. Alpha-keto amides and inorganic alkali react in an organic solvent for 6-18 hours at 110-150 DEG C, and the alpha-hydroxyamide is obtained through reduction. According to the preparation