102976-58-9Relevant academic research and scientific papers
Isomer-selective and enantiomerselective determination of DDT and related compounds using chiral high-resolution gas chromatography/mass spectrometry and chiral high-performance liquid chromatography
Buser, Hans-Rudolf,Mueller, Markus D.
, p. 2691 - 2698 (1995)
The composition of technical DDT was investigated using achiral and chiral high-resolution gas chromatography (HRGC) and electron-ionization mass spectrometry (EIMS). 2,4′-DDT and 2,4′-DDD, two important components of technical DDT, were enantiomerically resolved by chiral HRGC with silylated β-cyclodextrin and by chiral high-performance chromatography (HPLC) with permethylated γ-cyclodextrin as chiral selectors. The (+)- and (-)- enantiomers were assigned by chiral HPLC using chiroptical measurements. Enantiopure isolates were then used to identify these enantiomers in chiral HRGC analyses. Previous data indicated (+)- and (-)-2,4′-DDT to have S- and R-configuration, respectively, but the absolute configurations for (+)- and (-)-2,4′-DDD were hitherto unknown. They were now assigned via the reductive dechlorination of the individual 2,4′-DDT enantiomers which proceeded stereoselectively to the corresponding 2,4′-DDD enantiomers. The results showed (+)- and (-)-2,4′-DDD to have R- and S-configuration, respectively. The enantiomers of 2,4′-DDD thus have reversed signs of rotation for polarized light compared to the enantiomers of 2,4′-DDT with the same configuration. The enantiomer resolution of several additional chiral compounds in technical DDT is reported; enantiomeric ratios of ≈1.0 indicated all chiral compounds to be present as racemates in the technical and in the synthetic reference materials. We report the first enantioselective determinations of technical DDT; the methods presented should also be applicable to the analysis of environmental and biological samples.
Absolute configuration determination through the unique intramolecular excitonic coupling in the circular dichroisms of o,p′-DDT and o,p′-DDD. A combined experimental and theoretical study
Tanaka, Hiroki,Inoue, Yoshihisa,Nakano, Takeshi,Mori, Tadashi
, p. 606 - 610 (2017)
Circular dichroisms (CDs) of the o,p′-isomers of 1,1,1-trichloro- and 1,1-dichloro-2,2-bis(chlorophenyl)ethanes (DDT and DDD) were investigated experimentally and theoretically. A series of strong Cotton effect peaks in a characteristic negative-negative-positive-negative, or its mirror-imaged, pattern were observed in the CD spectra of these persistent organic pollutants. The theoretical CD spectra at the SAC-CI/B95(d) and RI-CC2/def2-TZVPP levels well reproduced the experimental ones, enabling us to unambiguously assign the absolute configuration of (+)-DDT and (-)-DDD as S.
Visible-light-promoted oxidative halogenation of alkynes
Li, Yiming,Mou, Tao,Lu, Lingling,Jiang, Xuefeng
, p. 14299 - 14302 (2019)
In nature, halogenation promotes the biological activity of secondary metabolites, especially geminal dihalogenation. Related natural molecules have been studied for decades. In recent years, their diversified vital activities have been explored for treating various diseases, which call for efficient and divergent synthetic strategies to facilitate drug discovery. Here we report a catalyst-free oxidative halogenation achieved under ambient conditions (halide ion, air, water, visible light, room temperature, and normal pressure). Constitutionally, electron transfer between the oxygen and halide ion is shuttled via simple conjugated molecules, in which phenylacetylene works as both reactant and catalyst. Synthetically, it provides a highly compatible late-stage transformation strategy to build up dihaloacetophenones (DHAPs).
THERAPEUTIC FOR HEPATIC CANCER
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, (2011/02/18)
A novel pharmaceutical composition for treating or preventing hepatocellular carcinoma and a method of treatment are provided. A pharmaceutical composition for treating or preventing liver cancer is obtained by combining a chemotherapeutic agent with an anti-glypican 3 antibody. Also disclosed is a pharmaceutical composition for treating or preventing liver cancer which comprises as an active ingredient an anti-glypican 3 antibody for use in combination with a chemotherapeutic agent, or which comprises as an active ingredient a chemotherapeutic agent for use in combination with an anti-glypican 3 antibody. Using the chemotherapeutic agent and the anti-glypican 3 antibody in combination yields better therapeutic effects than using the chemotherapeutic agent alone, and mitigates side effects that arise from liver cancer treatment with the chemotherapeutic agent.
Anti-Claudin 3 Monoclonal Antibody and Treatment and Diagnosis of Cancer Using the Same
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, (2010/05/13)
Monoclonal antibodies that bind specifically to Claudin 3 expressed on cell surface are provided. The antibodies of the present invention are useful for diagnosis of cancers that have enhanced expression of Claudin 3, such as ovarian cancer, prostate cancer, breast cancer, uterine cancer, liver cancer, lung cancer, pancreatic cancer, stomach cancer, bladder cancer, and colon cancer. The present invention provides monoclonal antibodies showing cytotoxic effects against cells of these cancers. Methods for inducing cell injury in Claudin 3-expressing cells and methods for suppressing proliferation of Claudin 3-expressing cells by contacting Claudin 3-expressing cells with a Claudin 3-binding antibody are disclosed. The present application also discloses methods for diagnosis or treatment of cancers.
Facile and catalytic degradation method of DDT using Pd/C-Et3N system under ambient pressure and temperature
Monguchi, Yasunari,Kume, Akira,Sajiki, Hironao
, p. 8384 - 8392 (2007/10/03)
The catalytic degradation method of p,p′-DDT [1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane] and its regioisomer o,p′-DDT [1,1,1-trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane] using the Pd/C-Et3N system under ambient hydrogen pressure and temperature was established. The presence of Et3N was necessary for the quick and complete breakdown of DDT. The independent degradation study of two intermediates, p,p′-DDD [2,2-bis(p-chlorophenyl)-1,1-dichloroethane] and p,p′-DDE [2,2-bis(p-chlorophenyl)-1,1-dichloroethylene] using GC-MS let us to speculate the degradation pathway of p,p′-DDT. In the initial phase of the reaction, p,p′-DDT degradation splits into two ways: a dehydrochlorination pathway and a hydrodechlorination pathway. In each pathway, reaction starts from an aliphatic moiety and subsequent hydrodechlorination from the benzene moieties takes place in a stepwise manner. The former pathway leads to the formation of 1,1-diphenylethane and the latter leads to the formation of 1,1-dichloro-2,2-diphenylethane. These diphenylethane analogs, which are less toxic compared with p,p′-DDT, are terminal degradation products in our system. The distinctive features of our catalytic degradation method of DDTs are reliability, simplicity, efficiency, and inexpensiveness.
Method of treating nausea and vomiting with certain substituted-phenylalkylamino (and aminoacid) derivatives and other serotonin depleting agents
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, (2008/06/13)
A method for the treatment of emesis in a mammal, which method comprises administering to said mammal an emesis inhibiting amount of a compound which depletes serotonin in the brain of mammals; among which are compounds having the formula: STR1 wherein, R is selected from hydrogen, loweralkyl, trifluoromethyl, carboxyl, or loweralkoxycarbonyl; R1 and R2 are hydrogen or loweralkyl; Z is trifluoromethyl or halogen; the optical isomers and pharmaceutically acceptable salts thereof; two of the preferred compounds of the invention are fenfluramine and norfenfluramine.
