102976-58-9Relevant articles and documents
Isomer-selective and enantiomerselective determination of DDT and related compounds using chiral high-resolution gas chromatography/mass spectrometry and chiral high-performance liquid chromatography
Buser, Hans-Rudolf,Mueller, Markus D.
, p. 2691 - 2698 (1995)
The composition of technical DDT was investigated using achiral and chiral high-resolution gas chromatography (HRGC) and electron-ionization mass spectrometry (EIMS). 2,4′-DDT and 2,4′-DDD, two important components of technical DDT, were enantiomerically resolved by chiral HRGC with silylated β-cyclodextrin and by chiral high-performance chromatography (HPLC) with permethylated γ-cyclodextrin as chiral selectors. The (+)- and (-)- enantiomers were assigned by chiral HPLC using chiroptical measurements. Enantiopure isolates were then used to identify these enantiomers in chiral HRGC analyses. Previous data indicated (+)- and (-)-2,4′-DDT to have S- and R-configuration, respectively, but the absolute configurations for (+)- and (-)-2,4′-DDD were hitherto unknown. They were now assigned via the reductive dechlorination of the individual 2,4′-DDT enantiomers which proceeded stereoselectively to the corresponding 2,4′-DDD enantiomers. The results showed (+)- and (-)-2,4′-DDD to have R- and S-configuration, respectively. The enantiomers of 2,4′-DDD thus have reversed signs of rotation for polarized light compared to the enantiomers of 2,4′-DDT with the same configuration. The enantiomer resolution of several additional chiral compounds in technical DDT is reported; enantiomeric ratios of ≈1.0 indicated all chiral compounds to be present as racemates in the technical and in the synthetic reference materials. We report the first enantioselective determinations of technical DDT; the methods presented should also be applicable to the analysis of environmental and biological samples.
Visible-light-promoted oxidative halogenation of alkynes
Li, Yiming,Mou, Tao,Lu, Lingling,Jiang, Xuefeng
, p. 14299 - 14302 (2019)
In nature, halogenation promotes the biological activity of secondary metabolites, especially geminal dihalogenation. Related natural molecules have been studied for decades. In recent years, their diversified vital activities have been explored for treating various diseases, which call for efficient and divergent synthetic strategies to facilitate drug discovery. Here we report a catalyst-free oxidative halogenation achieved under ambient conditions (halide ion, air, water, visible light, room temperature, and normal pressure). Constitutionally, electron transfer between the oxygen and halide ion is shuttled via simple conjugated molecules, in which phenylacetylene works as both reactant and catalyst. Synthetically, it provides a highly compatible late-stage transformation strategy to build up dihaloacetophenones (DHAPs).
Anti-Claudin 3 Monoclonal Antibody and Treatment and Diagnosis of Cancer Using the Same
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, (2010/05/13)
Monoclonal antibodies that bind specifically to Claudin 3 expressed on cell surface are provided. The antibodies of the present invention are useful for diagnosis of cancers that have enhanced expression of Claudin 3, such as ovarian cancer, prostate cancer, breast cancer, uterine cancer, liver cancer, lung cancer, pancreatic cancer, stomach cancer, bladder cancer, and colon cancer. The present invention provides monoclonal antibodies showing cytotoxic effects against cells of these cancers. Methods for inducing cell injury in Claudin 3-expressing cells and methods for suppressing proliferation of Claudin 3-expressing cells by contacting Claudin 3-expressing cells with a Claudin 3-binding antibody are disclosed. The present application also discloses methods for diagnosis or treatment of cancers.
