16308-14-8

Upstream product

• 696-62-8 para-iodoanisole 
• 64-19-7 acetic acid 
• 31599-50-5 4-methoxy(dichloroiodo)benzene 
• 127-09-3 sodium acetate 
• 6293-71-6 4,4'-dimethoxydiphenyliodonium iodide 
• 108-24-7 acetic anhydride 
• 75-07-0 acetaldehyde 
• 2754-27-0 trimethylsilyl acetate 

Downstream Products

• 125879-15-4 7-Methoxy-3-(4-methoxyphenyliodonio)-1-methyl-2-oxo-1,2-dihydro-4-chinolinolat 
• 102987-40-6 (3-(4-methoxyphenyl)prop-1-ynyl)trimethylsilane 
• 139553-93-8 [3-(2-Iodo-5-methoxy-phenyl)-prop-1-ynyl]-trimethyl-silane 
• 13540-76-6 3-(4-methoxyphenyl)prop-1-yne 
• 139553-92-7 1-(2-Iodo-5-methoxyphenyl)-2-propyne 
• 125879-16-5 1-Ethyl-7-methoxy-3-(4-methoxyphenyliodonio)-2-oxo-1,2-dihydro-4-chinolinolat 
• 696-62-8 para-iodoanisole 
• 64-19-7 acetic acid 
• 490-83-5 L-dehydroascorbic acid 
• 23383-01-9 (Dibenzoylmethan)-(4-methoxyphenyl)-iodonium-betain 
• 23383-00-8 (Benzoyl-acetylmethan)-(p-methoxyphenyl)-iodoniumbetain 
• 23382-97-0 Malonsaeuredimethylester-4-methoxy-phenyl-iodonium-betain 
• 23382-98-1 (Malonsaeurediethylester)-(4-methoxy-phenyl)-iodonium-betain 
• 161564-33-6 1--4-methoxybenzene 

Relevant academic research and scientific papers

Functionalization of closo-borates via iodonium zwitterions

A simple method for the functionalization of closo-borates [closo-B10H10]2- (1), [closo-1-CB9H10]- (2), [closo-B12H12]2- (3), [closo-1-CB11H

NMR study on the structure and stability of 4-substituted aromatic iodosyl compounds

Two 4-substituted aromatic iodosyl compounds were investigated with regard to their solubility, stability and chromatographic behaviour. 1-Iodosyl-4-methoxy- and 1-iodosyl-4-nitro-benzene are soluble in methanol and provide acceptable 1H and s

Aryl gemfibrozil derivative hypervalent iodine compound and preparation method thereof

The invention discloses an aryl gemfibrozil derivative hypervalent iodine compound and a preparation method thereof. The structural formula of the aryl gemfibrozil derivative hypervalent iodine compound is formula (I). The aryl gemfibrozil derivative hype

Preparation and Synthetic Applicability of Imidazole-Containing Cyclic Iodonium Salts

A novel approach to the preparation of imidazole-substituted cyclic iodonium salts has been developed via the oxidative cyclization of 1-phenyl-5-iodoimidazole using a cheap and available Oxone/H2SO4 oxidative system. The structure of the new polycyclic heteroarenes has been confirmed by single-crystal X-ray diffractometry, revealing the characteristic structure features for cyclic iodonium salts. The newly produced imidazole-flanked cyclic iodonium compounds were found to readily engage in a heterocyclization reaction with elemental sulfur, affording benzo[5,1-b]imidazothiazoles in good yields.

Aryl naproxen derivative high-valence iodine compound, preparation method and application thereof

The invention discloses an aryl naproxen derivative high-valence iodine compound, a preparation method and application thereof, wherein a series of naproxen derivatives are prepared through preparation and derivatization of naproxen high-valence iodine co

SYNTHESIS OF HYPERVALENT IODINE REAGENTS WITH DIOXYGEN

Methods of synthesis of hypervalent iodine reagents and methods for oxidation of organic compounds are disclosed.

Base/Cryptand/Metal-Free Automated Nucleophilic Radiofluorination of [18F]FDOPA from Iodonium Salts: Importance of Hydrogen Carbonate Counterion

As evidenced by the number of publications and patents published in the last years, the radiosynthesis of 6-[18F]fluoro-3,4-dihydroxy-L-phenylalanine ([18F]FDOPA) using the nucleophilic [18F]F- process remains currently a challenge for the radiochemists scientific community even if promising methods for the radiofluorination of electron-rich aromatic structures were recently developed from arylboronate, arylstannane or iodonium salt precursors. In such context, based on the use of an iodonium triflate salt precursor, we optimized a fast and efficient radiofluorination route fully automated and free from any base, cryptand or metal catalyst for the radiosynthesis of [18F]FDOPA. Using this method, this clinically relevant radiotracer was produced in 64 min, 27–38 % RCY d.c. (n = 5), >99 % RCP, >99 % ee., and high Am 170–230 GBq/μmol. In addition, this optimization study clearly highlighted the important role of a triflate-hydrogen carbonate counterion exchange during the radiolabeling process to achieve high fluorine-18 incorporation yields.

Iodine(III) Reagent-Mediated Intramolecular Amination of 2-Alkenylanilines to Prepare Indoles

A variety of 3-substituted and 2,3-disubstituted indoles were synthesized efficiently in good yields through the intramolecular amination of 2-alkenylanilines promoted by readily available iodine(III) reagents in a short reaction time. Mechanistic studies showed that the reaction pathway went through a nitrenium ion and that 3-acetoxy indoline was the key intermediate in the indole formation. The indole product was easily prepared on a gram scale and amination also proceeded smoothly using catalytic 3,5-dimethylphenyl iodine in the presence of mCPBA. Furthermore, the indolo[3,2-a]carbazole scaffold was prepared in good yield in six steps from commercial ortho-iodoaniline. (Figure presented.).

Safer Synthesis of (Diacetoxyiodo)arenes Using Sodium Hypochlorite Pentahydrate

A practical method for the preparation of (diacetoxyiodo)arene ArI(OAc)2 is described. The use of commercially available sodium hypochlorite pentahydrate (NaClO·5H2O) enabled safe, rapid, and inexpensive oxidation of iodoarenes with electron-withdrawing and -donating substituents. The method allows tandem divergent access to synthetically useful organo-λ3-iodanes such as hydroxyl(tosyloxy)iodobenzene, iodosylbenzene, iodonium ylide, etc.

Synthesis of 2-Quinolinones via a Hypervalent Iodine(III)-Mediated Intramolecular Decarboxylative Heck-Type Reaction at Room Temperature

A hypervalent iodine(III)-mediated intramolecular decarboxylative Heck-type reaction of 2-vinyl-phenyl oxamic acids has been developed. The unique ring-strain-enabled radical decarboxylation mechanism is preliminarily revealed. This protocol features metal-free reaction conditions and operational simplicity, allowing the lactamization of 2-vinylanilines using a readily accessible carbonyl source and the synthesis of various 2-quinolinones with excellent chemoselectivity at room temperature.