140-22-7 Usage
Chemical Properties
white crystals or powder
Uses
Different sources of media describe the Uses of 140-22-7 differently. You can refer to the following data:
1. 1,5-Diphenylcarbazideis a carbazide derivative used in the colorimteric determination of chromium as well as in the detection of cadmium, mercury, magnesium and aldehydes.
2. As indicator in titrating Fe; for the colorimetric determination of Cr, detection of Cd, Hg, Mg, aldehydes, emetine.
3. 1,5-Diphenylcarbazide is used in the colorimetric determination of chromium, osmium as well as in the detection of cadmium, mercury, magnesium, emetine and aldehydes.
General Description
1,5-Diphenylcarbazide is a colorimetric reagent commonly employed in the determination of trace metals.
Purification Methods
A common impurity is phenyl-semicarbazide which can be removed by chromatography: ~8g in H2O is placed on a column (polyamide 6 powder, Macherey-Nagel-GmbH-Germany, washed several times with MeOH), eluted with H2O/MeOH/AcOH (1:3:0.04) at 7-8 drops/second, then eluted with the same solvent mixture but diluted 5 fold with H2O. The purification is followed by UV light at 280nm. The effluent is evaporated to dryness in vacuo at ~28o. [chromatography, IR & UV: Willems et al. Anal Chim Acta 51 544 1970]. Recrystallise it from EtOH by adding CCl4 to induce crystallisation, or AcOH to give a white crystalline powder which turns pink in air. It is air and light sensitive and should be stored in the dark under N2. [Beilstein 15 H 292, 15 IV 182.]
Check Digit Verification of cas no
The CAS Registry Mumber 140-22-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,4 and 0 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 140-22:
(5*1)+(4*4)+(3*0)+(2*2)+(1*2)=27
27 % 10 = 7
So 140-22-7 is a valid CAS Registry Number.
InChI:InChI=1/C13H14N4O/c18-13(16-14-11-7-3-1-4-8-11)17-15-12-9-5-2-6-10-12/h1-10,14-15H,(H2,16,17,18)
140-22-7Relevant articles and documents
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Noller
, p. 1132 (1930)
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Efficient method of synthesis of N,N′-disubstituted ureas/thioureas by a Zinc chloride catalyzed thermal reaction
Pasha,Madhusudana Reddy
experimental part, p. 2928 - 2934 (2009/12/03)
Symmetrically N,N'-disubstituted ureas/thioureas were synthesized by heating amines or phenyl hydrazine and urea/thiourea on a preheated hot plate at 80-85C under solvent-free conditions in the presence of a catalytic amount of ZnCl2 as a catalyst. The protocol has the advantages of not using toxic phosgene and other hazardous substrates or organic solvents. Increased reaction rate, good yield, and a simple workup procedure are involved.
A novel method for the synthesis of disubstituted ureas and thioureas under microwave irradiaton
Mojtahedi, Mohammad M.,Saidi, Mohammad R.,Bolourtchian, Mohammad
, p. 710 - 711 (2007/10/03)
Several symmetrically disubstituted ureas and thioureas are synthesized by heating of urea or thiourea with aromatic amines or phenylhydrazine under environmentally benign conditions without any solvent in a conventional microwave oven.
