140-22-7

Usage

Chemical Properties

white crystals or powder

Uses

Different sources of media describe the Uses of 140-22-7 differently. You can refer to the following data:
1. 1,5-Diphenylcarbazideis a carbazide derivative used in the colorimteric determination of chromium as well as in the detection of cadmium, mercury, magnesium and aldehydes.
2. As indicator in titrating Fe; for the colorimetric determination of Cr, detection of Cd, Hg, Mg, aldehydes, emetine.
3. 1,5-Diphenylcarbazide is used in the colorimetric determination of chromium, osmium as well as in the detection of cadmium, mercury, magnesium, emetine and aldehydes.

General Description

1,5-Diphenylcarbazide is a colorimetric reagent commonly employed in the determination of trace metals.

Purification Methods

A common impurity is phenyl-semicarbazide which can be removed by chromatography: ~8g in H2O is placed on a column (polyamide 6 powder, Macherey-Nagel-GmbH-Germany, washed several times with MeOH), eluted with H2O/MeOH/AcOH (1:3:0.04) at 7-8 drops/second, then eluted with the same solvent mixture but diluted 5 fold with H2O. The purification is followed by UV light at 280nm. The effluent is evaporated to dryness in vacuo at ~28o. [chromatography, IR & UV: Willems et al. Anal Chim Acta 51 544 1970]. Recrystallise it from EtOH by adding CCl4 to induce crystallisation, or AcOH to give a white crystalline powder which turns pink in air. It is air and light sensitive and should be stored in the dark under N2. [Beilstein 15 H 292, 15 IV 182.]

InChI:InChI=1/C13H14N4O/c18-13(16-14-11-7-3-1-4-8-11)17-15-12-9-5-2-6-10-12/h1-10,14-15H,(H2,16,17,18)

Upstream product

• 861307-37-1 1-benzhydrylidene-5-phenyl carbonohydrazide 
• 6888-71-7 2,3-diphenyl-1,2,3,4-tetrazolium-5-olate 
• 100-63-0 phenylhydrazine 
• 57-13-6 urea 
• 75-44-5 phosgene 
• 60-29-7 diethyl ether 
• 108-88-3 toluene 
• 51-79-6 urethane 
• 103-03-7 1-phenylsemicarbazide 
• 102-07-8 bis(diphenyl)urea 
• 64-17-5 ethanol 
• 538-62-5 diphenylcarbazone 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 4453-80-9 3-nitro-1,5-diphenylformazan 

Downstream Products

• 52353-62-5 4-anilino-1-phenyl-1,2,4-triazolidine-3,5-dione 
• 860569-86-4 5-(3-nitro-phenyl)-1-phenyl-1,2-dihydro-[1,2,4]triazol-3-one 
• 151221-74-8 1-phenyl-5-styryl-1,2-dihydro-[1,2,4]triazol-3-one 
• 103-03-7 1-phenylsemicarbazide 
• 6942-46-7 1-phenylurazole 
• 19382-52-6 5-[2]furyl-1-phenyl-1,2-dihydro-[1,2,4]triazol-3-one 
• 21531-96-4 4-aminourazole 
• 103-02-6 acetone phenylhydrazone 
• 627-70-3 propan-2-one azine 
• 574-61-8 benzophenone N-phenylhydrazone 
• 106599-91-1 Pb(C₁₃H₁₁N₄O)2 
• 6888-71-7 2,3-diphenyl-1,2,3,4-tetrazolium-5-olate 
• 861621-96-7 1,5-dinitroso-1,5-diphenyl carbonohydrazide 
• 106478-54-0 1,5-diphenyl-carbazone; sodium salt 

Relevant academic research and scientific papers

A synthetic strategy for switching the single ion anisotropy in tetrahedral Co(II) complexes

Four novel mononuclear tetrahedral cobalt(ii) complexes containing exocyclic mesoionic ligands of molecular formulae [CoII(L1)(X)2(MeCN)] X = Cl (1) or Br (2) and [CoII(L2)(X)2(MeCN)], X = Cl (3) or Br (4) have been reported. It is found that simple substitution of L1 (O donor in 1 and 2) by L2 (S donor in 3 and 4) results in switching of the single ion magnetic anisotropy parameter (D) from positive to negative, with a significant change in magnitude.

Efficient method of synthesis of N,N′-disubstituted ureas/thioureas by a Zinc chloride catalyzed thermal reaction

Symmetrically N,N'-disubstituted ureas/thioureas were synthesized by heating amines or phenyl hydrazine and urea/thiourea on a preheated hot plate at 80-85C under solvent-free conditions in the presence of a catalytic amount of ZnCl2 as a catalyst. The protocol has the advantages of not using toxic phosgene and other hazardous substrates or organic solvents. Increased reaction rate, good yield, and a simple workup procedure are involved.

Efficient synthesis of N,N′-disubstituted ureas/thioureas catalyzed by iodine

Iodine is an efficient catalyst for the synthesis of symmetrically N,N′-disubstituted ureas/thioureas by heating respective amines or phenyl hydrazine and urea/thiourea on a preheated hot plate at 90-95°C, under solvent-free conditions. The yields are excellent, and the reactions go to complete within 5-10 min. Copyright Taylor & Francis Group, LLC.

A novel method for the synthesis of disubstituted ureas and thioureas under microwave irradiaton

Several symmetrically disubstituted ureas and thioureas are synthesized by heating of urea or thiourea with aromatic amines or phenylhydrazine under environmentally benign conditions without any solvent in a conventional microwave oven.