10307-60-5

Basic information

• Product Name: Methyl (2S)-2-methylbutanoate
• Synonyms: (S)-METHYL 2-METHYLBUTYRATE;(S)-2-Methylbutanoic acid methyl ester;(S)-Methyl 2-methylbutanoate;Methyl (2S)-2-methylbutanoate;OCWLYWIFNDCWRZ-YFKPBYRVSA-N
• CAS NO: 10307-60-5
• Molecular Formula: C₆H₁₂O₂
• Molecular Weight: 116.16
• EINECS: 212-778-0
• Mol File: 10307-60-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 113 °C
• Flash Point: 19 °C
• Appearance: /
• Density: 0.883
• Vapor Pressure: 21.6mmHg at 25°C
• Refractive Index: 1.395
• CAS DataBase Reference: Methyl (2S)-2-methylbutanoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl (2S)-2-methylbutanoate(10307-60-5)
• EPA Substance Registry System: Methyl (2S)-2-methylbutanoate(10307-60-5)

Safety Data

• Hazardous Substances Data: 10307-60-5(Hazardous Substances Data)

Usage

General Description

Methyl (2S)-2-methylbutanoate, also known as methyl (S)-2-methylbutyrate, is an organic compound with a fruity and apple-like odor. It is commonly used as a flavoring agent in the food and beverage industry, particularly in the production of fruit-flavored products. This ester is also utilized in the fragrance industry for its pleasant aroma, and in the pharmaceutical industry as an intermediate in the synthesis of various pharmaceutical compounds. Additionally, it can be used as a solvent in various chemical and industrial processes. Methyl (2S)-2-methylbutanoate is considered safe for consumption and is generally recognized as safe (GRAS) by the Food and Drug Administration (FDA) in the United States.

InChI:InChI=1/C6H12O2/c1-4-5(2)6(7)8-3/h5H,4H2,1-3H3

Upstream product

• 186581-53-3 diazomethane 
• 1730-91-2 (S)-2-Methylbutyric acid 
• 50285-38-6 ((R)-1-Ethyl-prop-2-ynyl)-carbamic acid methyl ester 
• 124-41-4 sodium methylate 
• 77-76-9 2,2-dimethoxy-propane 
• 80-59-1 Tiglic acid 
• 1346946-90-4 C₁₂H₁₆O₂S 
• 1346946-88-0 C₁₄H₁₇NO₃S 
• 77-78-1 dimethyl sulfate 
• 3586-58-1 2-methylenebutyric acid 
• 1467762-13-5 (11S)-jalapinolic acid 11-O-α-L-rhamnopyranosyl-(1→3)-O-[3-O-(trans-cinnamoyl)-4-O-(2S-methylbutanoyl)-α-L-rhamnopyranosyl-(1→4)]-O-(2-O-n-decanoyl)-α-L-rhamnopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-O-β-D-glucopyranoside-(1,3''-lactone) 
• 1467762-15-7 cairicoside C 
• 137542-42-8 3-[(2E)-2-methyl-1-oxo-2-buten-1-yl]-2-oxazolidinone 
• 67-56-1 methanol 

Downstream Products

• 10574-37-5 2,3-dimethylpent-2-ene 
• 28357-68-8 (S)-2,3-Dimethyl-2-pentanol 
• 4911-70-0 (R)-2,3-Dimethyl-2-pentanol 
• 70195-11-8 ((S)-2-methyl-butyryl)-hydrazine 

Relevant articles and documents

Four new pentasaccharide resin glycosides from Ipomoea cairica with strong α-glucosidase inhibitory activity

Six pentasaccharide resin glycosides from Ipomoea cairica, including four new acylated pentasaccharide resin glycosides, namely cairicoside I-IV (1-4) and the two known compounds cairicoside A (5) and cairicoside C (6), were isolated from the aerial parts of Ipomoea cairica. Their structures were established by a combination of spectroscopic, including two dimensional (2D) NMR and chemical methods. The core of the six compounds was simonic acid A, and they were esterfied the same sites, just differing in the substituent groups. The lactonization site of the aglycone was bonded to the second saccharide moiety at C-2 in 1-4, and at C-3 in 5-6. Compounds 1 and 5, 4 and 6 were two pairs of isomers. The absolute configuration of the aglycone in 1-6 which was (11S)-hydroxyhexadecanoic acid (jalapinolic acid) was established by Mosher's method. Compounds 1-4 have been evaluated for inhibitory activity against α-glucosidase, which all showed inhibitory activities.

Three new resin glycosides compounds from Argyreia acuta and their α-glucosidase inhibitory activity

Three new phenolic compounds, acutacoside C (1), acutacoside D (2) and acutacoside E (3) were isolated from the aerial part of Argyreia acuta. The oligosaccharide chain was composed of two glucoses and three rhamnoses, and the aglycone was (11S)-hydroxyhexadecanoic acid (jalapinolic acid). The core of the three compounds was operculinic acid B, which was rare in resin glycosides. Their structures were established by a combination of spectroscopic and chemical methods. Compounds 1-3 have been evaluated for inhibitory activity against α-glucosidase, which all showed weak inhibitory activities.

Heterogeneous catalytic hydrogenation of olefinic substrates by poly-NAP

With our previously described poly-NAP, various olefinic substrates were reduced with selectivities comparable to those obtained by BINAP. For substrates which contained a methyl ester, the selectivities were higher than those observed for their carboxylic acid analogues. (C) 2000 Elsevier Science Ltd.

Enantioselective enolate protonation in sulfamichael addition to r-substituted n-acryloyloxazolidin-2-ones with bifunctional organocatalyst

Organocatalytic conjugate addition of thiols to R-substituted N-acryloyloxazolidin-2-ones followed by asymmetric protonation has been studied in the presence of cinchona alkaloid derived thioureas. Both of the enantiomers are accessible with the same level of enantioselectivity using pseudoenantiomeric quinine/quinidine derived catalysts. The addition/protonation products have been converted to useful biologically active molecules. 2011 American Chemical Society.