1031400-91-5

Upstream product

• 150242-80-1 C₁₇H₁₇ClO₂ 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 150242-78-7 methyl 4-(benzyloxy)-3-n-propylbenzoate 
• 105211-78-7 methyl 4-hydroxy-3-n-propylbenzoate 
• 53596-60-4 methyl 3-allyl-4-hydroxybenzoate 
• 35750-24-4 methyl 4-allyloxybenzoate 
• 99-76-3 methyl 4-hydroxylbenzoate 

Downstream Products

• 1031393-87-9 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-(4-methoxyphenyl)-5-methylimidazolidine-2,4-dione 
• 1031395-11-5 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methyl-5-phenylimidazolidine-2,4-dione 
• 1031393-48-2 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methyl-5-(p-tolyl)imidazolidine-2,4-dione 
• 1031393-53-9 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-(4-isopropylphenyl)-5-methylimidazolidine-2,4-dione 
• 1031393-91-5 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-(2-methoxyphenyl)-5-methylimidazolidine-2,4-dione 
• 1031394-30-5 5-(3,4-dimethoxyphenyl)-3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methylimidazolidine-2,4-dione 
• 1031393-95-9 5-(4-ethoxyphenyl)-3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methylimidazolidine-2,4-dione 
• 1031394-02-1 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-(4-(1-methylethoxy)phenyl)-5-methylimidazolidine-2,4-dione 
• 1031394-11-2 3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methyl-5-(4-(trifluoromethoxy)phenyl)imidazolidine-2,4-dione 
• 1258059-59-4 5-(benzo[d][1,3]dioxol-5-yl)-3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methylimidazolidine-2,4-dione 
• 1031394-36-1 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxy-propan-2-yl)-2-n-propylphenoxy)butyl)-5-methylimidazolidine-2,4-dione 
• 1031393-83-5 5-(4-(dimethylamino)phenyl)-3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methylimidazolidine-2,4-dione 
• 1031393-64-2 5-(4-chlorophenyl)-3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methylimidazolidine-2,4-dione 
• 1031394-16-7 5-([1,1'-biphenyl]-4-yl)-3-(4-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-n-propylphenoxy)butyl)-5-methylimidazolidine-2,4-dione 

Relevant academic research and scientific papers

Design, synthesis and pharmacology of 1,1-bistrifluoromethylcarbinol derivatives as liver X receptor β-selective agonists

A novel series of 1,3-bistrifluoromethylcarbinol derivatives that act as liver X receptor (LXR) β-selective agonists was discovered. Structure-activity relationship studies led to the identification of molecule 62, which was more effective (Emax) and selective toward LXRβ than T0901317 and GW3965. Furthermore, 62 decreased LDL-C without elevating the plasma TG level and significantly suppressed the lipid-accumulation area in the aortic arch in a Bio F1B hamster fed a diet high in fat and cholesterol. We demonstrated that our LXRβ agonist would be potentially useful as a hypolipidemic and anti-atherosclerotic agent. In this manuscript, we report the design, synthesis and pharmacology of 1,3-bistrifluoromethylcarbinol derivatives.

CARBINOL DERIVATIVES HAVING CYCLIC LINKER

[Object] To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate.

SUBSTITUTED CARBINOL COMPOUND

There is provided a novel LXRβ agonist useful as a preventative and/or therapeutic agent for arteriosclerosis; arteriosclerosis such as those resulting from diabetes; hyperlipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases caus